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Table 7 Comparison of performance between datasets (SEPSIS score ≥ 5)

From: Derivation and internal validation of the screening to enhance prehospital identification of sepsis (SEPSIS) score in adults on arrival at the emergency department

Estimate Derivation cohort
n = 16063
Validation cohort
n = 6882
Undifferentiated medical cases (estimate(95% confidence interval))
 Sensitivity 0.39 (0.35–0.43) 0.37 (0.31–0.44)
 Specificity 0.96 (0.96–0.96) 0.96 (0.96–0.97)
 Positive predictive value 0.27 (0.24–0.30) 0.27 (0.23–0.32)
 Negative predictive value 0.98 (0.97–0.98) 0.98 (0.97–0.98)
 Positive likelihood ratio 9.48 (8.35–10.76) 9.72 (7.96–11.87)
 Negative likelihood ratio 0.64 (0.60–0.68) 0.65 (0.59–0.72)
Infection present (estimate(95% confidence interval))
 Sensitivity 0.39 (0.35–0.43) 0.37 (0.31–0.44)
 Specificity 0.99 (0.98–0.99) 0.98 (0.98–0.99)
 Positive predictive value 0.50 (0.45–0.55) 0.49 (0.42–0.56)
 Negative predictive value 0.98 (0.97–0.98) 0.98 (0.97–0.98)
 Positive likelihood ratio 26.1 (22.2–30.1) 24.8 (19.3–31.9)
 Negative likelihood ratio 0.62 (0.58–0.66) 0.64 (0.58–0.70)