A prospective pilot study using metabolomics discloses specific fatty acid, catecholamine and tryptophan metabolic pathways as possible predictors for a negative outcome after severe trauma

Table 1 Demographic and clinical characteristics according to mortality

	ALL (n = 48)	SURVIVORS (n = 43)	NON SURVIVORS (n = 5)	p ^*
Age (years)^a	47,5 ± 19	45,7 ± 19	63,0 ± 10	0,057
Sex (Male) (%)	85,4	83,7	100,0	0,438
Traffic (%)	62,5	62,8	60,0	0,706
Severe Brain Injury (Glasgow score < = 8) (%)	37,5	34,9	60,0	0,272
Glasgow (score)	13 ± 3	13 ± 3	14 ± 3	0,533
MV (%)	37,5	30,2	100,0	0,005
NA (%)	33,3	30,2	60,0	0,316
PaO2/FiO2	305 ± 111	310 ± 112	265 ± 99	0,429
LOS (days)^b	13(8–24)	16(8–28)	9(4–14)	0,001
APACHE II	11,6 ± 6	10,7 ± 6	19,0 ± 5	0,010
ISS	19,0 ± 9	18,9 ± 9	20,2 ± 7	0,511

Both APACHE II and ISS scores are directly proportional to severity of injury
MV Mechanical ventilation, NA noradrenaline perfusion, PaO2/FiO2 Arterial Partial Pressure of Oxygen/Fraction of Inspired Oxygen, LOS Length of stay, APACHE II Acute Physiology and Chronic Health Evaluation II (ranges between 0 and 67), ISS Injury Severity Score (ranges between 0 and 75)
^*p value after group comparison by χ² or Mann-Whitney test for continuous variables
^amean ± standard deviation
^bmedian (interquartile interval)

ISSN: 1757-7241