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Table 3 Consultation characteristics and indications for reversal

From: Application of prothrombin complex concentrate for reversal of direct oral anticoagulants in clinical practice: indications, patient characteristics and clinical outcomes compared to reversal of vitamin K antagonists

  Total (n = 346) DOAC (n = 74) Vitamin K antagonist (n = 272) p
Triage
 Acute life threating problem 123 (35.5) 38 (51.4) 85 (31.2)  
 High urgency 142 (41.0) 25 (33.8) 117 (43.0)  
 Urgency 70 (20.2) 10 (13.5) 60 (22.1)  
 Less urgency 4 (1.2) 0 (0.0) 4 (1.5)  
 Missing 7 (2.0) 1 (1.4) 6 (2.2) 0.024
Laboratory valuesa
 Haemoglobin (g/l) 122 (105–136) 117.5 (97–135) 122 (107–136) 0.094
 Creatinine (μmol/l) 90 (71–123) 85.0 (71–118) 91 (71–125) 0.432
 Platelets (G/l) 209 (168–262) 199.5 (169–271) 211 (168–254) 0.832
 INR 2.0 (1.3–2.9) 1.2 (1.1–1.4) 2.3 (1.6–3.1) < 0.001
 Trauma 129 (37.3) 26 (35.1) 103 (37.9) 0.666
 Outpatient discharge 2 (0.6) 1 (1.4) 1 (0.4) 0.322
Indication for reversal
 Bleeding 300 (86.7) 69 (93.2) 231 (84.9)  
 Endoscopy 10 (2.9) 1 (1.4) 9 (3.3)  
 Drainage, centesis, puncture 18 (5.2) 3 (4.1) 15 (5.5)  
 Emergency operation 18 (5.2) 1 (1.4) 17 (6.2) 0.245
  1. Abbreviation: DOAC direct oral anticoagulants, INR international normalised ratio
  2. aData available for 94.2, 99.1, 83.2%, or 99.1% for the values haemoglobin, creatinine, platelets, or INR