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Table 3 Consultation characteristics and indications for reversal

From: Application of prothrombin complex concentrate for reversal of direct oral anticoagulants in clinical practice: indications, patient characteristics and clinical outcomes compared to reversal of vitamin K antagonists

 

Total (n = 346)

DOAC (n = 74)

Vitamin K antagonist (n = 272)

p

Triage

 Acute life threating problem

123

(35.5)

38

(51.4)

85

(31.2)

 

 High urgency

142

(41.0)

25

(33.8)

117

(43.0)

 

 Urgency

70

(20.2)

10

(13.5)

60

(22.1)

 

 Less urgency

4

(1.2)

0

(0.0)

4

(1.5)

 

 Missing

7

(2.0)

1

(1.4)

6

(2.2)

0.024

Laboratory valuesa

 Haemoglobin (g/l)

122

(105–136)

117.5

(97–135)

122

(107–136)

0.094

 Creatinine (μmol/l)

90

(71–123)

85.0

(71–118)

91

(71–125)

0.432

 Platelets (G/l)

209

(168–262)

199.5

(169–271)

211

(168–254)

0.832

 INR

2.0

(1.3–2.9)

1.2

(1.1–1.4)

2.3

(1.6–3.1)

< 0.001

 Trauma

129

(37.3)

26

(35.1)

103

(37.9)

0.666

 Outpatient discharge

2

(0.6)

1

(1.4)

1

(0.4)

0.322

Indication for reversal

 Bleeding

300

(86.7)

69

(93.2)

231

(84.9)

 

 Endoscopy

10

(2.9)

1

(1.4)

9

(3.3)

 

 Drainage, centesis, puncture

18

(5.2)

3

(4.1)

15

(5.5)

 

 Emergency operation

18

(5.2)

1

(1.4)

17

(6.2)

0.245

  1. Abbreviation: DOAC direct oral anticoagulants, INR international normalised ratio
  2. aData available for 94.2, 99.1, 83.2%, or 99.1% for the values haemoglobin, creatinine, platelets, or INR