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Table 4 Surviving sepsis campaign hour-1 bundle of care elements

From: Sepsis: mechanisms of bacterial injury to the patient

• Measure lactate levela
• Obtain blood cultures before administering antibiotics.
• Administer broad-spectrum antibiotics.
• Begin rapid administration of 30 ml/kg crystalloid for hypotension or lactate level ≥ 4 mmol/L.
• Apply vasopressors if hypotensive during or after fluid resuscitation to maintain MAP ≥65 mmHg.
  1. aRemeasure lactate if initial lactate is elevated (> 2 mmol/L)