Table 1 Study characteristics
Study | Country | Study design | Jadad Quality score/Newcastle-Ottawa scale (NOS) | Participants | Intervention | Control |
|---|---|---|---|---|---|---|
Bickell 1994 | USA | Single-center, prospective RCT | Three out of five -No double blind | Gunshot or stab wounds to the torso who had SBP<90 mmHg | Delayed resuscitation with RLS 10ml/hr until definitive treatment | Immediate resuscitation to maintain SBP at least 100 mmHg |
Dutton 2002 | USA | Single-center, prospective RCT | Three out of five -No double blind | Traumatic hemorrhagic shock with SBP <90 mmHg and evidence of ongoing bleeding | Low SBP of 70 mmHg | Conventional SBP > 100 mmHg |
WANG Mei-tang 2007 | China | Single-center, prospective cohort study | Selection: 3 Comparability: 2 Outcome: 2 | Traumatic hemorrhagic shock | Preoperative SBP approximately 70-80 mmHg | Preoperative SBP >90 mmHg |
ZHENG Wei-hua 2007 | China | Single-center, prospective, RCT | Two out of five -No method of randomization -No double blind | Traumatic hemorrhagic shock patients | Limited fluid resuscitation (MAP 50-60 mmHg) | Aggressive fluid resuscitation (MAP 70 mmHg) |
HUA Li-dain 2010 | China | Prospective, RCT | Two out of five -No method of randomization -No double blind | Severe multiple hemorrhagic shock | Limited fluid resuscitation (SBP 70 mmHg) | Observational with MAP at least 90/60 mmHg |
WANG Aitian 2010 | China | Prospective, RCT | Two out of five -No method of randomization -No double blind | Traumatic hemorrhagic shock | Limited fluid resuscitation to maintain SBP 70 mmHg | Conventional resuscitation to maintain SBP 100 mmHg |
Fan Hai-Peng 2011 | China | Prospective, RCT | Two out of five -No method of randomization -No double blind | Pelvic fracture with hemorrhagic shock | Low MAP 50-60 mmHg or SBP 70-90 mmHg | Conventional MAP 60-80 mmHg or SBP >100 mmHg |
Morrison 2011 | China | Single-center, prospective, two-arm, intention to treat, RCT | Three out of five -No double blind | Patients undergoing laparotomy or thoracotomy for blunt and penetrating trauma who had SBP < 9o mmHg | Experimental group with MAP 50 mmHg | Control group with MAP 65 mmHg |
Fan Hai-Peng 2012 | China | Single-center, RCT | Two out of five -No method of randomization -No double blind | Hepatic and splenic injury with hemorrhagic shock | Limited fluid resuscitation (MAP 50-60 mmHg) | Conventional resuscitation (SBP 100 mmHg or MAP 60-80 mmHg) |
LI Wenhao 2012 | China | Prospective, RCT | Two out of five -No method of randomization -No double blind | Traumatic hemorrhagic shock without controlling bleeding | Limited fluid resuscitation (MAP 55 mmHg) | Adequate fluid resuscitation (MAP 75mm Hg) |
Chen Mu-hu 2013 | China | Prospective, RCT | Two out of five -No method of randomization -No double blind | Traumatic hemorrhagic shock patients | Limited fluid resuscitation (SBP 70 mmHg) | Aggressive fluid resuscitation (SBP 90 mmHg) |
ZHAO yong-gang 2013 | China | Retrospective cohort study | Selection: 4 Comparability: 2 Outcome: 2 | Traumatic hemorrhagic shock patients | Objective group (SBP 85 mmHg, limited fluid) | Control group (SBP >90 mmHg, rapid and full replenishment of fluid |
WANG Xiao-guo 2014 | China | Prospective, RCT | Two out of five -No method of randomization -No double blind | Traumatic liver and splenic injury | Limited fluid resuscitation (MAP 50-70 mmHg) | Conventional resuscitation (MAP 70-90 mmH) |
ZENG Fan-yuan 2014 | China | Single-center, cohort study | Selection: 4 Comparability: 2 Outcome: 2 | Uncontrolled traumatic hemorrhagic shock patients | Experimental group (MAP 50 mmHg) | Control group (MAP 70 mmHg) |
Chen Mianzhan 2015 | China | Prospective, RCT | Two out of five -No method of randomization -No double blind | Traumatic hemorrhagic shock patients | Limited resuscitation (SBP at least 80 mmHg) | Conventional resuscitation (SBP at least 90 mmHg) |
Chen Yuan-bing, 2015 | China | Prospective, RCT | Two out of five -No method of randomization -No double blind | Traumatic hemorrhagic shock patients | Limited resuscitation (SBP 70 mmHg) | Conventional resuscitation (SBP >90 mmHg) |
Huang Ting 2015 | China | Prospective, RCT | Two out of five -No method of randomization -No double blind | Traumatic hemorrhagic shock | Control group with MAP 40-60 mmHg | Observation group with MAP 60-90 mmHg |
Schreiber 2015 | USA | Multi-center, RCT | Three out of five -No double blind | Blunt or penetrating trauma patients with SBP <90 mmHg | Administer 250 ml of fluid if SBP <70 mmHg or absent radial pulse | Administer 2 liters initially and additional fluid as needed to maintain SBP > 110 mmHg |
Wen Zhen-jie 2015 | China | Multi-center, prospective cohort studies | Selection: 4 Comparability: 2 Outcome: 2 | Traumatic hemorrhagic shock | Limited fluid resuscitation (SBP 75 mmHg) | Conventional fluid resuscitation (SBP > 100 mmHg) |
XU Guoping 2015 | China | Single center, prospective RCT | Two out of five -No method of randomization -No double blind | Traumatic hemorrhagic shock patients | Limited fluid resuscitation (MAP 40-60 mmHg or SBP 70 mmHg) | Conventional resuscitation (MAP 60-80 mmHg or SBP > 90 mmHg) |
YAO Jian-hui 2015 | China | Single center, prospective, RCT | Two out of five -No method of randomization -No double blind | Multiple traumatic hemorrhagic shock patients | Limited fluid resuscitation (MAP 40-50 mmHg) | Active fluid resuscitation (MAP 60-80 mmHg) |
Carrick 2016 | USA | Single-center, prospective, two-arm, intention-to-treat, RCT | Three out of five -No double blind | Penetrating trauma patients with SBP < 90 mmHg who were brought emergently to OR for bleeding control | Keep low MAP (MAP 50 mmHg) | Keep normotension (MAP at least 65 mmHg) |
Dai Yulong, 2016 | China | Prospective, RCT | Two out of five -No method of randomization -No double blind | Traumatic hemorrhagic shock patients | Limited fluid resuscitation (SBP 65 mmHg) | Conventional resuscitation (SBP 90 mmHg) |
Wang Fengyong 2016 | China | Single center, prospective RCT | Two out of five -No method of randomization -No double blind | Active hemorrhagic shock | Limited fluid resuscitation (maintain MAP 40-60 mmHg) | Conventional resuscitation (maintain MAP 60-90 mmHg) |