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Table 2 Prediction models with retained variables at the four time points following ICU admission

From: A prediction model for good neurological outcome in successfully resuscitated out-of-hospital cardiac arrest patients

Variables Hour 1 (χ2 = 0.95) Hour 12 (χ2 = 0.90) Hour 24 (χ2 = 0.96) Hour 48 (χ2 = 0.99)
Estimate (SE) P-value Estimate (SE) P-value Estimate (SE) P-value Estimate (SE) P-value
Intercept −4.462 (1.258) < 0.001 −1.213 (2.297) 0.598 − 3504 (2.242) 0.118 − 1.124 (1.544) 0.467
Female −1.819 (0.843) 0.031 −1.244 (0.763) 0.103 −1.622 (0.939) 0.085
Age −0.032 (0.028) 0.245 −0.025 (0.025) 0.332
Absence of diabetes 1.196 (0.725) 0.099 1.673 (0.982) 0.089 2.014 (0.977) 0.039 1.880 (1.176) 0.110
Initial rhythm
 Ventricular fibrillation 2.213 (0.734) 0.003 0.653 (0.915) 0.475 1.204 (0.872) 0.168 0.717 (0.960) 0.455
 Pulseless electrical activity 0.861 (0.972) 0.376 −1.456 (1.234) 0.238 −0.139 (1.228) 0.910 −0.504 (1.387) 0.716
No PCI −0.776 (0.553) 0.160 −0.630 (0.752) 0.402 −0.210 (0.662) 0.751 −0.315 (0.734) 0.668
Absence of BIS value of 0 1.966 (0.751) 0.009 3.717 (0.942) < 0.001 3.139 (0.898) 0.001 2.878 (0.942) 0.002
Mean BIS at respective hour 0.017 (0.014) 0.231 0.027 (0.016) 0.085 0.033 (0.019) 0.092
Lactate at respective hour −0.219 (0.187) 0.242 − 0.216 (0.235) 0.358 − 0.136 (0.533) 0.799
Creatinine at respective hour −0.331 (0.310) 0.287
NSE    −0.023 (0.016) 0.153
  1. BIS Bispectral Index,NSE Neuron-specific enolase, PCI Percutaneous coronary intervention, SE Standard error, χ2 chi-square statistic indicating the goodness-of-fit
  2. These are the final multivariate logistic regression models with retained variables based on the elastic-net method
  3. • Variables considered to be included at all time points: sex, age, diabetes status, witnessed arrest, initial rhythm (with asystole as reference category), PCI, initial lactate, initial haemoglobin, initial creatinine, mean arterial pressure, BIS value of 0, mean BIS, mean cerebral oxygen saturation
  4. • Variables considered to be included at hour 12, 24 and 48: lactate, haemoglobin and creatinine and mixed venous oxygen saturation at respective time points
  5. • Variable considered to be included at hour 24 and 48: NSE at respective time points