|
Variables
|
Hour 1 (χ2 = 0.95)
|
Hour 12 (χ2 = 0.90)
|
Hour 24 (χ2 = 0.96)
|
Hour 48 (χ2 = 0.99)
|
|---|
|
Estimate (SE)
|
P-value
|
Estimate (SE)
|
P-value
|
Estimate (SE)
|
P-value
|
Estimate (SE)
|
P-value
|
|---|
|
Intercept
|
−4.462 (1.258)
|
< 0.001
|
−1.213 (2.297)
|
0.598
|
− 3504 (2.242)
|
0.118
|
− 1.124 (1.544)
|
0.467
|
|
Female
|
–
|
–
|
−1.819 (0.843)
|
0.031
|
−1.244 (0.763)
|
0.103
|
−1.622 (0.939)
|
0.085
|
|
Age
|
–
|
–
|
−0.032 (0.028)
|
0.245
|
−0.025 (0.025)
|
0.332
|
–
|
–
|
|
Absence of diabetes
|
1.196 (0.725)
|
0.099
|
1.673 (0.982)
|
0.089
|
2.014 (0.977)
|
0.039
|
1.880 (1.176)
|
0.110
|
|
Initial rhythm
|
|
Ventricular fibrillation
|
2.213 (0.734)
|
0.003
|
0.653 (0.915)
|
0.475
|
1.204 (0.872)
|
0.168
|
0.717 (0.960)
|
0.455
|
|
Pulseless electrical activity
|
0.861 (0.972)
|
0.376
|
−1.456 (1.234)
|
0.238
|
−0.139 (1.228)
|
0.910
|
−0.504 (1.387)
|
0.716
|
|
No PCI
|
−0.776 (0.553)
|
0.160
|
−0.630 (0.752)
|
0.402
|
−0.210 (0.662)
|
0.751
|
−0.315 (0.734)
|
0.668
|
|
Absence of BIS value of 0
|
1.966 (0.751)
|
0.009
|
3.717 (0.942)
|
< 0.001
|
3.139 (0.898)
|
0.001
|
2.878 (0.942)
|
0.002
|
|
Mean BIS at respective hour
|
0.017 (0.014)
|
0.231
|
0.027 (0.016)
|
0.085
|
0.033 (0.019)
|
0.092
|
–
|
–
|
|
Lactate at respective hour
|
–
|
–
|
−0.219 (0.187)
|
0.242
|
− 0.216 (0.235)
|
0.358
|
− 0.136 (0.533)
|
0.799
|
|
Creatinine at respective hour
|
–
|
–
|
−0.331 (0.310)
|
0.287
|
–
|
–
|
–
|
–
|
|
NSE
| | |
–
|
–
|
−0.023 (0.016)
|
0.153
|
- BIS Bispectral Index,NSE Neuron-specific enolase, PCI Percutaneous coronary intervention, SE Standard error, χ2 chi-square statistic indicating the goodness-of-fit
- These are the final multivariate logistic regression models with retained variables based on the elastic-net method
- • Variables considered to be included at all time points: sex, age, diabetes status, witnessed arrest, initial rhythm (with asystole as reference category), PCI, initial lactate, initial haemoglobin, initial creatinine, mean arterial pressure, BIS value of 0, mean BIS, mean cerebral oxygen saturation
- • Variables considered to be included at hour 12, 24 and 48: lactate, haemoglobin and creatinine and mixed venous oxygen saturation at respective time points
- • Variable considered to be included at hour 24 and 48: NSE at respective time points
