Variables

Hour 1 (χ^{2} = 0.95)

Hour 12 (χ^{2} = 0.90)

Hour 24 (χ^{2} = 0.96)

Hour 48 (χ^{2} = 0.99)


Estimate (SE)

Pvalue

Estimate (SE)

Pvalue

Estimate (SE)

Pvalue

Estimate (SE)

Pvalue


Intercept

−4.462 (1.258)

< 0.001

−1.213 (2.297)

0.598

− 3504 (2.242)

0.118

− 1.124 (1.544)

0.467

Female

–

–

−1.819 (0.843)

0.031

−1.244 (0.763)

0.103

−1.622 (0.939)

0.085

Age

–

–

−0.032 (0.028)

0.245

−0.025 (0.025)

0.332

–

–

Absence of diabetes

1.196 (0.725)

0.099

1.673 (0.982)

0.089

2.014 (0.977)

0.039

1.880 (1.176)

0.110

Initial rhythm

Ventricular fibrillation

2.213 (0.734)

0.003

0.653 (0.915)

0.475

1.204 (0.872)

0.168

0.717 (0.960)

0.455

Pulseless electrical activity

0.861 (0.972)

0.376

−1.456 (1.234)

0.238

−0.139 (1.228)

0.910

−0.504 (1.387)

0.716

No PCI

−0.776 (0.553)

0.160

−0.630 (0.752)

0.402

−0.210 (0.662)

0.751

−0.315 (0.734)

0.668

Absence of BIS value of 0

1.966 (0.751)

0.009

3.717 (0.942)

< 0.001

3.139 (0.898)

0.001

2.878 (0.942)

0.002

Mean BIS at respective hour

0.017 (0.014)

0.231

0.027 (0.016)

0.085

0.033 (0.019)

0.092

–

–

Lactate at respective hour

–

–

−0.219 (0.187)

0.242

− 0.216 (0.235)

0.358

− 0.136 (0.533)

0.799

Creatinine at respective hour

–

–

−0.331 (0.310)

0.287

–

–

–

–

NSE
  
–

–

−0.023 (0.016)

0.153

 BIS Bispectral Index,NSE Neuronspecific enolase, PCI Percutaneous coronary intervention, SE Standard error, χ^{2} chisquare statistic indicating the goodnessoffit
 These are the final multivariate logistic regression models with retained variables based on the elasticnet method
 • Variables considered to be included at all time points: sex, age, diabetes status, witnessed arrest, initial rhythm (with asystole as reference category), PCI, initial lactate, initial haemoglobin, initial creatinine, mean arterial pressure, BIS value of 0, mean BIS, mean cerebral oxygen saturation
 • Variables considered to be included at hour 12, 24 and 48: lactate, haemoglobin and creatinine and mixed venous oxygen saturation at respective time points
 • Variable considered to be included at hour 24 and 48: NSE at respective time points