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Table 4 Subgroup analysis

From: Head-to-head comparison of qSOFA and SIRS criteria in predicting the mortality of infected patients in the emergency department: a meta-analysis

Subgroup No. of studies No. of patients RR (95% CI) SEN (95% CI) SPE (95% CI) Test for heterogeneity (I2)
All studies
 qSOFA 8 52,849 4.55 (3.38–6.14) 0.42 (0.31–0.54) 0.88 (0.83–0.92) 91.1
 SIRS 8 52,849 2.75 (1.96–3.86) 0.81 (0.75–0.86) 0.41 (0.32–0.50) 89
Prospective studies
 qSOFA 4 11,122 5.34 (4.19–6.82) 0.39 (0.22–0.60) 0.90 (0.83–0.94) 37.2
 SIRS 4 11,122 3.23 (1.95–4.33) 0.80 (0.67–0.89) 0.47 (0.38–0.56) 78.5
Retrospective studies
 qSOFA 4 41,727 3.95 (2.48–6.44) 0.44 (0.38–0.50) 0.85 (0.80–0.90) 86.2
 SIRS 4 41,727 2.35 (1.40–3.93) 0.83 (0.78–0.87) 0.34 (0.21–0.49) 84.4
In-hospital mortality
 qSOFA 5 41,372 4.20 (3.18–5.56) 0.49 (0.41–0.57) 0.84 (0.81–0.86) 86.6
 SIRS 5 41,372 2.97 (1.84–4.80) 0.85 (0.81–0.88) 0.35 (0.25–0.46) 81.8
30-day mortality
 qSOFA 3 11,477 5.22 (2.70–10.07) 0.41 (0.37–0.46) 0.92 (0.92–0.93) 84.1
 SIRS 3 11,477 2.42 (1.40–4.23) 0.74 (0.69–0.78) 0.54 (0.53–0.55) 81.4
The initial values
 qSOFA 5 35,462 3.29 (2.51–4.29) 0.33 (0.22–0.47) 0.90 (0.82–0.94) 79.1
 SIRS 5 35,462 1.93 (1.20–3.15) 0.78 (0.68–0.86) 0.37 (0.25–0.51) 92.1
The worst values
 qSOFA 3 17,387 6.89 (5.12–9.27) 0.55 (0.47–0.63) 0.87 (0.82–0.90) 71
 SIRS 3 17,387 4.24 (3.50–5.14) 0.85 (0.75–0.91) 0.46 (0.35–0.57) 0
  1. qSOFA quick Sequential Organ Failure Assessment, SIRS systemic inflammatory response syndrome, RR risk ratio, SEN sensitivity; SPE specificity; CI confidence interval