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Table 3 Laboratory values upon emergency room admission

From: The impact of direct oral anticoagulants in traumatic brain injury patients greater than 60-years-old

  no ATT PI VKA DOAC p value
Hb 13.7 (12.4–14.6) 13.5 (11.5–14.9) 13.3 (11.7–14.2) 12.8 (11.8–13.8) ns
PTI 104 (95–112) 102 (91–115) 30.5 (23.5–36.0) 70 (56.5–83) < 0.0001
INR 0.98 (0.93–1.04) 1 (0.93–1.06) 2.51 (2.04–3.24) 1.3 (1.1–1.97) < 0.0001
aPTT 26.9 (25.1–28.8) 27.9 (26.6–30.2) 39.7 (34.6–41.9) 34.1 (28.8–41.0) < 0.0001
PLT 228 (182–262) 206 (162.5–257.5) 181 (165–212.5) 216 (172–257) 0.0355
S 100β initial 0.66 (0.28–1.53) 0.34 (0.12–0.95) 0.35 (0.13–1.13) 0.25 (0.12–0.97) ns
Creatinine 0.88 (0.74–1.02) 0.9 (0.67–1.09) 1.02 (0.8–1.29) 1 (0.8–1.2) ns
GFR 70.6 (51.5–93.4) 64.18 (48.7–87.7) 56.6 (44.1–72.5) 58.7 (44.3–76.1) ns
AST 25 (20–39) 22 (17.25–29) 27 (19–34) 25 (17–34.5) ns
Multiplate®
 ASPI* (n = 16, 23, 6, 5) 86.5 (42.5–117.8) 19 (11–39) 61 (20–115) 68 (33–125) 0.0084
 ADP (n = 16, 11, 6, 5) 87.5 (62.25–115.3) 50 (33–84) 72.5 (40–135) 86 (66–116) ns
 TRAP (n = 16, 10, 6,5) 124 (88.5–146.8) 99.5 (93.3–112.3) 109.5 (94.3–128.5) 127 (108.5–152.5) ns
  1. No-ATT no antithrombotic therapy, PI platelet inhibitors, VKA vitamin K antagonists DOAC, direct oral anticoagulants, Hb haemoglobin, PTI prothrombin time index, aPTT activated partial thromboplastin time, INR international normalized ratio, PLT platelet count, GFR glomerular filtration rate, AST Aspartate Aminotransferase, ASPI-test arachidonic acid test, ADP-test adenosine diphosphate test, TRAP-test thrombin receptor activated peptide test, ns not significant
  2. ANOVA and Dunnett’s comparison of all columns vs. control column
  3. Median (interquartile range, 25th–75th)