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Table 5 Reports focused on extracorporeal membrane oxygenation used in patients presenting traumatic brain injury

From: Predictors of hospital mortality in adult trauma patients receiving extracorporeal membrane oxygenation for advanced life support: a retrospective cohort study

Author
(Country; Year)
Therapeutic
purpose
Severity of TBI Case Number;
Median age (y)/ ISS
Device
/ER-to-device time
Anticoagulation/
Hemorrhagic event
Mortality/
Median Device Time
Reynolds[19]
(USA/1999)
Ventilation assistance TBI (AIS 3)
ICP monitor: No
1 case;
16/18
VV-ECMO
/0 (d)
Heparin free/
Pulmonary hemorrhage
No
/7 (d)
Yen [20]
(Taiwan/2008)
Hemodynamic assistance TBI (AIS 5)
ICP monitor: Yes
1 case;
21/NA*
VA-ECMO
/2 (d)
Heparin free/
No hemorrhagic event
No
/49 hours
Messing [21]
(USA/2014)
Ventilation assistance TBI (AIS ≥ 3)
ICP monitor: Yes
1 case;
21/38
VV-ECMO
/3 (d)
Initial heparin free then ACT 180-200 s/
No hemorrhagic event
No
/20 (d)
Muellenbach [22]
(Germany/2012)
Ventilation assistance TBI (AIS ≥ 3)
ICP monitor: Yes
3 cases;
53/59, 16/66, 28/66
VV-ECMO
/2 (d), 0 (d), 0(d)
Initial heparin free then aPTT 40-60 s/
No hemorrhagic event
No
/8 (d), 3 (d), 3(d)
Munoz-Bendix [23]
(Germany/2015)
Reducing PaCO2 for ICP reduction TBI (AIS >3)
ICP monitor: Yes
10 cases;
50 /NA*
pECLA
/ 6(d)
aPTT 50-60 s/
NA*
NA*
/8 (d)
Biscotti [24]
(USA/2015)
Ventilation assistance TBI (AIS >3),
ICP monitor: Yes
2 cases;
18/27, 20/33
VV-ECMO
/4 (d), 4(d)
aPTT 40-60 s/
No hemorrhagic event
No
/ 6(d), 13 (d)
Zhou [25]
(China/2015)
Ventilation assistance
during tracheal repair
TBI (AIS 3),
ICP monitor: No
1 case;
33/34
VA-ECMO
/4 (d)
ACT 300 (s)/
No hemorrhagic event
No
/551 minutes
Robba [26]
(UK/2017)
Ventilation assistance TBI (AIS ≥ 3)
ICP monitor: Yes
2 cases;
31/41, 54/32
VV-ECMO
/5 (d), 20 (d)
NA*/
No hemorrhagic event
50% (n=1)
/20 (d), 4 (d)
  1. ACT: Active clotting time. APTT: Activated partial thromboplastin time. ECMO: Extracorporeal membrane oxygenation. ICP: Intracranial pressure monitor. pECLA: Pumpless extracorporeal lung assist. TBI: Traumatic brain injury. VA: Venoarterial. VV: Venovenous
  2. *NA: Not available