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Table 4 Discriminative performance of individual disease severity scores for each group

From: The most commonly used disease severity scores are inappropriate for risk stratification of older emergency department sepsis patients: an observational multi-centre study

  AUC Sensitivity Specificity PPV NPV
Total cohort
 MEDS (≥7) 0.80 (0.76–0.83) 0.81 (0.80–0.83) 0.62 (0.60–0.64) 0.12 (0.10–0.13) 0.98 (0.97–0.99)
 PIRO (≥14) 0.73 (0.69–0.77) 0.55 (0.53–0.57) 0.77 (0.75–0.79) 0.12 (0.11–0.14) 0.96 (0.95–0.97)
 qSOFA (≥1) 0.68 (0.63–0.72) 0.83 (0.81–0.84) 0.47 (0.44–0.49) 0.10 (0.09–0.11) 0.98 (0.97–0.98)
 qSOFA (≥2) 0.68 (0.63–0.72) 0.32 (0.30–0.33) 0.87 (0.85–0.88) 0.11 (0.10–0.12) 0.95 (0.94–0.96)
 MEWS (≥7) 0.63 (0.58–0.67) 0.42 (0.40–0.44) 0.77 (0.76–0.79) 0.11 (0.10–0.13) 0.95 (0.94–0.96)
 NEWS (≥8) 0.67 (0.62–0.72) 0.63 (0.61–0.65) 0.63 (0.61–0.65) 0.10 (0.08–0.11) 0.96 (0.95–0.97)
Patients age < 70
 MEDS (≥7) 0.86 (0.82–0.91) 0.83 (0.81–0.85) 0.78 (0.76–0.80) 0.14 (0.12–0.15) 0.99 (0.98–0.99)
 PIRO (≥9) 0.78 (0.73–0.84) 0.87 (0.85–0.89) 0.56 (0.54–0.59) 0.08 (0.07–0.10) 0.99 (0.98–0.99)
 qSOFA (≥1) 0.72 (0.66–0.78) 0.83 (0.81–0.85) 0.55 (0.52–0.57) 0.08 (0.06–0.09) 0.98 (0.98–0.99)
 qSOFA (≥2) 0.72 (0.66–0.78) 0.28 (0.25–0.30) 0.92 (0.90–0.93) 0.10 (0.08–0.11) 0.96 (0.95–0.97)
 MEWS (≥5) 0.66 (0.60–0.73) 0.73 (0.70–0.75) 0.51 (0.49–0.54) 0.06 (0.05–0.08) 0.97 (0.97–0.98)
 NEWS (≥8) 0.72 (0.65–0.78) 0.65 (0.63–0.68) 0.70 (0.68–0.73) 0.09 (0.07–0.10) 0.98 (0.97–0.98)
Patients age > =70
 MEDS (≥9) 0.64 (0.57–0.71) 0.62 (0.59–0.66) 0.60 (0.56–0.63) 0.13 (0.11–0.16) 0.94 (0.92–0.95)
 PIRO (≥16) 0.62 (0.55–0.69) 0.46 (0.42–0.49) 0.77 (0.74–0.80) 0.15 (0.13–0.18) 0.93 (0.91–0.95)
 qSOFA (≥1) 0.60 (0.53–0.66) 0.82 (0.80–0.85) 0.30 (0.27–0.33) 0.11 (0.09–0.13) 0.94 (0.92–0.95)
 qSOFA (≥2) 0.60 (0.53–0.66) 0.35 (0.32–0.38) 0.77 (0.74–0.80) 0.12 (0.10–0.14) 0.92 (0.90–0.94)
 MEWS (≥7) 0.56 (0.49–0.63) 0.42 (0.38–0.45) 0.71 (0.68–0.74) 0.12 (0.10–0.14) 0.92 (0.90–0.94)
 NEWS (≥10) 0.57 (0.50–0.64) 0.45 (0.41–0.48) 0.69 (0.66–0.72) 0.12 (0.10–0.14) 0.92 (0.90–0.94)
  1. Optimal cut-off points are shown in parentheses for every disease severity score. Outcomes are shown as mean with 95% confidence interval
  2. Abbreviations: qSOFA quick sepsis-related organ dysfunction assessment score, PIRO predisposition, infection, response, and organ dysfunction score, MEDS mortality in emergency department sepsis score, MEWS modified early warning score, NEWS national early warning score, AUC Area under the curve, PPV Positive predictive value, NPV Negative predictive value