Table 1 Patient characteristics of patients <70 and ≥70 years of age
Total cohort | <70 years | ≥70 years | |
|---|---|---|---|
Demographics | |||
N (%) | 2280 | 1497 (65.7) | 783 (34.3) |
Age, mean (SD) [1] | 61.1 (17.0) | 52.2 (13.6) | 78.2 (6.2) |
Gender (male), n (%) [1] | 1315 (57.7) | 821 (54.8) | 494 (63.1) |
Included at University Medical Centre, n (%) | 1860 (81.6) | 1271 (84.9) | 589 (75.2) |
Co-morbidities, n (%) | |||
COPD [2] | 349 (15.3) | 158 (10.6) | 191 (24.4) |
Heart failure [1] | 329 (14.4) | 133 (8.9) | 196 (25.0) |
Liver disease [1] | 113 (5.0) | 94 (6.3) | 19 (2.4) |
Renal disease [1] | 416 (18.2) | 261 (17.4) | 155 (19.8) |
Nursing home [2] | 138 (6.1) | 46 (3.1) | 92 (11.7) |
Immune-compromised [2] | 951 (41.7) | 720 (48.1) | 231 (29.5) |
Malignancy – [1] | 253 (11.1) | 155 (10.4) | 98 (12.5) |
Malignancy + [3] | 345 (15.1) | 244 (16.3) | 101 (12.9) |
DNR status (%) (6) | 478 (21.0) | 185 (12.4) | 293 (37.4) |
Suspected source of infection, n (%) | |||
Pulmonary | 1059 (46.4) | 620 (41.4) | 439 (56.1) |
Urogenital | 675 (29.6) | 397 (26.5) | 278 (35.5) |
Abdominal | 396 (17.4) | 273 (18.2) | 123 (15.7) |
Skin | 198 (8.7) | 145 (9.7) | 53 (6.8) |
Neurological | 48 (2.1) | 35 (2.3) | 13 (1.7) |
other | 396 (17.4) | 301 (20.1) | 95 (12.1) |
Vital signs on admission | |||
Systolic blood pressure, mean (SD) (241) | 131.9 (25.9) | 129.8 (23.5) | 135.7 (29.3) |
Heart rate, mean (SD) (45) | 108.0 (20.3) | 110.2 (19.7) | 103.8 (20.9) |
Respiratory rate, mean (SD) (558) | 24.0 (7.2) | 22.83 (6.9) | 25.73 (7.5) |
Oxygen saturation, mean (SD) (71) | 95.2 (4.8) | 95.8 (4.6) | 94.1 (5.2) |
Temperature (°C), mean (SD) (94) | 38.72 (1.11) | 38.74 (1.06) | 38.69 (1.20) |
Altered mental status n (%) (420) | 370 (16.2) | 161 (10.8) | 209 (26.7) |
Laboratory analysis on admission | |||
Lactate (mmol/l), median (IQR) (293) | 1.9 (1.4–2.6) | 1.8 (1.4–2.6) | 2.0 (1.5–2.8) |
Platelets (×109/l), median (IQR) (41) | 209 (151–280) | 207 (148–279) | 213.5 (156–286) |
INR median (IQR), (702) | 1.1 (1–1.4) | 1.1 (1.0–1.29) | 1.2 (1.0–2.4) |
Creatinine (μg/l), median (IQR) [16] | 87 (67–120) | 83 (64–110) | 95 (74–134) |
Urea (mmol/l), median (IQR) (40) | 7.0 (5.1–10.2) | 6.2 (4.6–8.8) | 8.8 (6.6–12.5) |
Band cells >5%, n (%) | 179 (7.9) | 103 (6.9) | 76 (9.7) |
Bilirubin (μmol/l), median (IQR) (349) | 12 (8–19) | 12 (8–18) | 12 (9–20) |
Treatment variables | |||
Time to antibiotics (min), median (IQR) [23] | 103 (58–167) | 109 (63–174) | 91 (51–152) |
Fluid resuscitation (L during ED stay), median (IQR) | 1 (0.5–1.5) | 1 (0.5–1.5) | 1 (0.5–1.5) |
Supplementary oxygen (L/min), median (IQR) (85) | 3 (0–5) | 2 (0–5) | 3 (2–6) |