Effect of dextran-70 on outcome in severe sepsis; a propensity-score matching study

Table 3 Fluid therapy

	Propensity score matched groups
	Control, n = 245		Dextran, n = 245		P
	Median	Q1 to Q3	Median	Q1 to Q3
Dextran-70, 60 mg/ml (ml)
Day 1	0	0 to 0	1000	500 to 1000	<0.001
Day 2	0	0 to 0	0	0 to 500	<0.001
Day 3	0	0 to 0	0	0 to 0	<0.001
Mean per day^a	0	0 to 0	399	200 to 654	<0.001
Albumin 50 mg/ml (ml)
Day 1	0	0 to 500	0	0 to 500	0.17
Day 2	0	0 to 0	0	0 to 0	0.0.66
Day 3	0	0 to 0	0	0 to 0	0.80
Mean per day	99	0 to 253	50	0 to 219	0.03
Albumin 200 mg/ml (ml)
Day 1	0	0 to 154	0	0 to 0	<0.001
Day 2	0	0 to 100	0	0 to 0	0.24
Day 3	0	0 to 100	0	0 to 81	0.71
Mean per day	43	0 to 121	17	0 to 80	<0.001
Crystalloids^b (ml)
Day 1	2100	533 to 4000	3025	2000 to 4200	<0.001
Day 2	78	0 to 420	130	0 to 985	0.06
Day 3	0	0 to 200	27	0 to 300	0.09
Mean per day	1050	343 to 2104	1279	740 to 2162	0.13
Blood transfusion (ml)
Day 1	0	0 to 328	250	0 to 600	<0.001
Day 2	0	0 to 0	0	0 to 295	0.008
Day 3	0	0 to 0	0	0 to 245	0.88
Mean per day	57	0 to 244	174	0 to 320	<0.001
Fluids in, total^c (ml)
Day 1	4261	1942 to 6323	5700	3999 to 7475	<0.001
Day 2	2817	1852 to 3982	3699	2684 to 4645	<0.001
Day 3	2444	1253 to 3322	2924	2088 to 3964	0.006
Mean per day	3823	2413 to 4891	4544	3314 to 5600	<0.001
Urine output (ml)
Day 1	1400	605 to 2545	1073	381 to 2076	0.009
Day 2	2243	1049 to 3622	1931	829 to 3211	0.04
Day 3	2640	1410 to 3850	2555	1025 to 3743	0.92
Mean per day	2010	376 to 3044	2078	327 to 3007	0.97
Total fluid balance^d (ml)
Day 1	1989	0 to 4528	3516	1703 to 5732	<0.001
Day 2	0	−627 to 1550	995	0 to 2617	<0.001
Day 3	−1	−1361 to 323	−38	−896 to 841	0.11
Mean per day	581	−82 to 2015	1022	204 to 2264	0.03

The number of patients in the control group was: Day 1 = 245. Day 2 = 191. Day 3 = 138. Day 4 = 102. Day 5 = 79. The number of patients in the dextran group was: Day 1 = 245. Day 2 = 212. Day 3 = 175. Day 4 = 139. Day 5 = 124. The data were collected from the patient’s electronic charts. No missing values. The decreasing number of patients represents patients who died or were discharged from the ICU
^aMean per day represents mean fluid administration per day up to 5 days after admission. For patients with ICU-stay <5 days the mean per day was calculated for the length of stay
^bCrystalloids represents the sum of NaCl 9 mg/ml and Ringer’s Acetate
^cFluids in, total represents the sum of all enteral and parenteral administered fluids including blood products
^dInsensible perspiration not included

ISSN: 1757-7241