Clinical course and prognostic factors of patients in severe accidental hypothermia with circulatory instability rewarmed with veno-arterial ECMO - an observational case series study

Sylweriusz Kosiński; Tomasz Darocha; Anna Jarosz; Aleksander Zeliaś; Mirosław Ziętkiewicz; Paweł Podsiadło; Tomasz Sanak; Kinga Sałapa; Jacek Piątek; Janusz Konstany-Kalandyk; Robert Gałązkowski; Paweł Krawczyk; Łukasz Krzych; Rafał Drwiła

doi:10.1186/s13049-017-0388-7

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

Table 2 Characteristics of survivors and non-survivors

From: Clinical course and prognostic factors of patients in severe accidental hypothermia with circulatory instability rewarmed with veno-arterial ECMO - an observational case series study

Parameter	Survivors (n = 9)	Non-survivors (n = 4)
Age [years]	Me 57 IQR [55–60]	Me 73 IQR [64.5–82.5]
Tc at hospital admission [°C]	26.07 ± 1.51	25.32 ± 3.24
SBP at hospital admission [mmHg]	74.4 ± 8.82	57.5 ± 5
DBP at hospital admission [mmHg]	47.2 ± 7.55	35 ± 5.77
pH at hospital admission	7.14 ± 0.08	7.02 ± 0.15
pH after achieving normothermia	Me 7.32 IQR [7.32–7.33]	Me 7.23 IQR [7.03–7.32]
EtCO₂ at hospital admission	17.3 ± 1.5	14.5 ± 2.5
PaCO₂ at hospital admission [mmHg]	41.4 ± 8.2	26.4 ± 7.4
PaCO₂ after achieving normothermia [mmHg]	Me 31.4 IQR [28.7–31.8]	Me 24.5 IQR [19.2–29.6]
PaO₂ at hospital admission [mmHg]	232.5 ± 117.7	107.6 ± 50.7
Lactate level (mmol/l) at hospital admission	6.89 ± 5.94	12.57 ± 4.55
Lactate level (mmol/l) after achieving normothermia	Me 2.9 IQR [1.4–3.6]	Me 12.2 IQR [8.4–15.3]
Lactate clearance 6 h	46.9%	5.7%
Lactate clearance 24 h	73.0%	34.8%
Lactate clearance at normothermia	56.0%	5.7%
BE at hospital admission [mEq/L]	-14.322 ± 4.82	-23.45 ± 4.33
BE after achieving normothermia [mEq/L]	Me -9.2 IQR [-11.4 – -7.7]	Me -14 IQR [-22.1– -12.1]
HCO₃ at hospital admission [mmol/L]	13.889 ± 4.09	7.225 ± 1.63
HCO₃ after achieving normothermia [mmol/L]	16.389 ± 3.37	9.850 ± 4.78
K at hospital admission [mmol/L]	3.022 ± .76	4.975 ± .85
Na at hospital admission [mmol/L]	137.6 ± 6.4	143.2 ± 16.1
Glucose at hospital admission [mmol/L]	8.2 ± 2.97	6.1 ± 1.07
Creatinine at hospital admission [μmol/L]	Me 85 IQR [64–114]	Me 194 IQR [139-376]
CK at hospital admission [U/L]	Me 1374 IQR [1114–2397]	Me 4664 IQR [1724–18054]
CK 6 h [U/L]	Me 1195 IQR [495–4168]	Me 1948 IQR [595–6830]
CK-MB at hospital admission [U/L]	Me 115 IQR [100–132]	Me 278 IQR [164–394]
CK-MB 6 h [U/L]	Me 70 IQR [54–183]	Me 180 IQR [125-–249]
hsTnT at hospital admission [nmol/L]	Me 0.033 IQR [0.027–0.048]	Me 0.082 IQR [0.073–0.203]
hsTnT 6 h [nmol/L]	Me 0.064 IQR [0.038–0.372]	Me 0.097 IQR [0.091–0.17]
INR at hospital admission	1.46 ± .28	1.61 ± .23
APTT 0 h	37.7 ± 10.7	35.9 ± 15.1
PLT at hospital admission [10³/uL]	142 ± 66	124 ± 110
Hb at hospital admission [g/dl]	12.13 ± 4.0	10.90 ± 3.66
Hb after achieving normothermia [g/dl]	9.54 ± 1.94	9.15 ± 1.21

Continuous data presented with mean value with standard deviation (normal distribution) or as median with lower and upper quartiles (non-normal distribution). M denotes mean value; Me median, IQR interquartile interval

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