Thrombocytopenia on the first day of emergency department visit predicts higher risk of acute kidney injury among elderly patients

Table 3 Regression analyses with AKI after ED stay as the dependent variable

Cox proportional hazard regression	Hazard ratio	95% CI	p value
Model 1: PLT count as variable
Comorbid CKD	1.88	1.11–3.2	0.02
Comorbid CHF	1.86	0.96–3.59	0.07
SBP at ED (per mmHg)	0.984	0.975–0.994	< 0.01
Platelet count (per 10³/μL)	0.997	0.994–0.999	0.02
Model 2: thrombocytopenia or not as variable
Comorbid CKD	1.96	1.15–3.32	0.01
Comorbid CHF	1.96	1.01–3.83	0.048
SBP at ED (per mmHg)	0.984	0.974–0.993	< 0.01
Thrombocytopenia	1.86	1.06–3.27	0.03
^aSensitivity analyses: Model S1, PLT count as variable
Comorbid CKD	1.77	1.01–3.09	0.04
Comorbid CHF	2.51	1.23–5.14	0.01
Comorbid malignancy	1.82	0.99–3.34	0.05
DBP at ED (per mmHg)	0.971	0.954–0.988	< 0.01
Platelet count (per 10³/μL)	0.997	0.994–0.999	0.01
^aSensitivity analyses: Model S2, thrombocytopenia or not as variable
Comorbid CKD	1.99	1.16–3.39	0.01
Comorbid CHF	1.93	0.99–3.74	0.05
SBP at ED (per mmHg)	0.983	0.973–0.993	< 0.01
Thrombocytopenia	1.85	1.05–3.28	0.03

Model 1 and 2 included demographic features (age and gender), all comorbidities in Table 1, vital sign parameters (blood pressure and heart rates), and first laboratory data obtained (leukocytes, hemoglobin, and platelet counts)
^aSensitivity analysis models included demographic features (age and gender), all comorbidities in Table 1, vital sign parameters (blood pressure and heart rates), first laboratory data obtained (leukocytes, hemoglobin, and platelet counts), and use of NSAID, vancomycin, and contrast
Abbreviations: AKI acute kidney injury, CI confidence interval, CKD chronic kidney disease, CHF congestive heart failure, DBP diastolic blood pressure, ED emergency department, NSAID non-steroidal anti-inflammatory drug, PLT platelet, SBP systolic blood pressure

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