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Table 1 Summary of studies included in the review

From: A systematic review on the rotational thrombelastometry (ROTEM®) values for the diagnosis of coagulopathy, prediction and guidance of blood transfusion and prediction of mortality in trauma patients

Author, region

Study design, centers, patients, years

N

Objective

ISS (mean ± SD or median/IQR)

Age (mean or median)

Sex male, n (%)

Rugeri, 2006 [36]

France

Single center prospective, civilian, Jul 2004-Oct 2004

88

Detect coagulopathy

Guide transfusion

22 (12–34)

34 (±16)

68 (77 %)

Levrat, 2008 [37]

France

Single center prospective, civilian, Jul 2004-Oct 2004

87

Diagnosis of HF

Control group: 20 (11–29)

HF group: 75 (75–75)

Control: 29 (21–43)

HF: 30 (24–45)

Control: 64/82 (78 %)

HF: 4/5 (80 %)

Schochl, 2009 [26]

Austria

Single center prospective, civilian, Jan 2003-Dec 2007

33

Diagnosis of HF

Predict mortality

47 ± 14

45 (20–88)

22 (67 %)

Doran, 2010 [25]

Afghanistan

Single center prospective, military, Jan 2009-Mar 2009

25

Detect coagulopathy

MT group: 35 (25–50)

Non MT: 20 (19–20)

21 (18–35)

25 (100 %)

Leemann, 2010 [38]

Zurich

Single center retrospective, civilian, Jan 2006-Dec 2006

53

Predict MT

31.1 ± 1.7

39.6 (±2.5)

40 (75.5 %)

Schochl, 2010 [27]

Austria

Single center retrospective, civilian, Jan 2005-Apr 2009

131

Guide transfusion

38 ± 15

46 ± 18

96 (73 %)

Tauber, 2011 [40]

Austria

Single center, prospective, civilian, Jul 2005-Jul 2008

334

Detect coagulopathy

Predict RBC transfusion

Predict mortality

34 (24–45)

43 (27–56)

260 (77.8 %)

Schochl, 2011 [39]

Austria

Single center, retrospective, civilian, Jan 2005-Oct 2010

88

Predict mortality

Survivors: 20 (16–26.25)

Non survivors 29 (25–30.75)

47 (26–66)

67 (76 %)

Schochl, 2011 [28]

Austria

Single center retrospective, civilian, Jan 2005-Dec 2010

323

Predict mortality

Non-MT group: 27 (20–34)

MT group: 42 (34–50)

44 (26–59)

245 (78 %)

Davenport, 2011 [41]

United Kingdom

Single center prospective, civilian, Jan 2007-Jun 2009

300

Detect coagulopathy

Predict MT

12 (4–25)

33 (23–48)

246 (82 %)

Rourke, 2012 [42]

England

Multicenter prospective, civilian, Jan 2008-Dec 2010

517

Detect coagulopathy

Guide transfusion

14 (8–27)

36 (23–51)

405 (78 %)

Woolley, 2013 [30]

Afghanistan

Single center prospective, military, May 2009-Jul 2009

48

Predict coagulopathy

34 (17–43)

24 (21–26)

48 (100 %)

Hagemo 2015 [43]

Multi center prospective civilian, Jan 2007-Nov2011

808

Detect coagulopathy,

Predict MT

16 (20)

38 (28)

625 (77.4 %)

  1. Legend: FC fibrinogen concentrate, CA5 amplitude of the clot at 5 min, CA10 amplitude of the clot at 10 min, ISS injury severity score, HF hyperfibrinolysis, MCF maximum clot firmness MT massive transfusion, ROTEM®® rotational thromboelastometry, SLTs standard laboratory tests, TBI traumatic brain injury