System | Parameter | Clinical implications |
---|---|---|
• Initial vasoconstriction (effect blocked by ethanol). Vasoconstriction fails <24 °C [268]. | • Failed vasoconstriction means the patient becomes poikilothermic i.e. dependent on ambient temperature. | |
• Cardiac conduction is affected by cold and changes in pH and PaO2 [79]. Initial tachycardia due to shivering [79] subsides as temperature drops due to decreased spontaneous depolarization of pacemaker cells leading to linear fall in pulse rate (~50 % at 28 °C) [79]. Any ECG rhythm is possible. Commonly at <32 °C, sinus bradycardia, prolonged QTc. J waves (not pathognomonic for hypothermia) best seen in leads I & V6 [79, 269–272]. Likelihood of VF is high <28 °C [267]. | • Bradycardia is atropine unresponsive [79]. • A “relative” tachycardia inconsistent with patient’s temperature means something else is going on e.g. occult trauma. • Be prepared for any rhythm but expect it to be resistant to treatment until the heart rewarms. • Normal rhythm resumes on rewarming. | |
• Cardiac output falls to 45 % at 25 °C [79]. | • Hypotension is the norm. | |
• After rewarming, mean arterial pressure, contractility, and cardiac output are decreased, especially if alcohol ingested before cooling [273]. | • More prolonged depression of cardiac function after rewarming | |
CENTRAL NERVOUS SYSTEM | • Reflexes become increasingly sluggish as body temperature falls and become absent ≈ 28–30 °C [230, 274]. • Pupils become dilated and cease reacting to light at ≈ 28 °C [230]. • EEG shows burst suppression ≈ 22 °C and becomes isoelectric ≈ 18–20 °C [79, 275]. | • The level of consciousness should be consistent with the core temperature. A significant discrepancy suggests an alternative diagnosis. • All the effects of hypothermia make it very hard to diagnose death by the usual criteria while the patient is still cold |
RESPIRATORY | • Tidal volume, respiratory rate, pulmonary compliance and thoracic elasticity decrease [230]. The respiratory rate may only be five breaths per minute when the body temperature is <30 °C [79]. Sensitivity to CO2 is attenuated, although the hypoxic drive is maintained to deeper levels of hypothermia [230]. Cough reflex is obtunded, ciliary activity is reduced and secretions are more viscous. | • An irregular respiratory pattern can be mistaken for agonal breathing leading to premature institution of CPR. • The likelihood of a chest infection is increased. |
• Oxygen consumption and carbon dioxide production fall by about 50 % at 30 °C [230] | • Reduced CO2 production means it is easy to inadvertently hyperventilate hypothermic patients. Hyperoxia is also possible. | |
RENAL & METABOLIC | • Cold diuresis, partly due to the relative central hypervolaemia resulting from peripheral vasoconstriction [79], but also from a reduction in ADH release and resistance to its effects [230]. Alcohol will further increase the diuresis. | • Severely hypothermic patients are dehydrated. This becomes particularly important during rewarming as the consequent opening up of the peripheral circulation will lead to a rapid fall in BP. |
• Hyperglycaemia is common due to catecholamine-induced glycogenolysis, decreased insulin release and inhibition of insulin transport [79, 267]. | • Hyperglycaemia can exacerbate the diuresis. | |
• Glomerular filtration rate falls as cardiac output and hence renal blood flow fall [230]. At low temperatures, tubular capacity for H+ secretion is reduced, and hence there is a renal component of the acidosis [230]. | • This makes the interpretation of acid-base more complex. | |
• Hypokalaemia commonly occurs with hypothermia [230]. | • If potassium replacement is given excess to the losses, hyperkalaemia may occur on rewarming [276, 277]. • Severe initial hyperkalaemia is a marker of acidosis and cell death and is therefore a sign of poor prognosis [8] | |
HAEMATOLOGY | • Haematocrit increases by about 2 % for every 1 °C decline in temperature [250]. | • A normal haematocrit in a moderately or severely hypothermic patient suggests pre-existing anaemia or blood loss [230]. |
COAGULATION | • Platelet function and coagulation enzyme activity are reduced [278]. | • Coagulopathy is likely and increases with decreasing core temperature. At temperatures below 33 °C coagulopathy significantly increases mortality in patients with concomitant trauma [279]. |