Fig. 1From: The endothelial glycocalyx and its disruption, protection and regeneration: a narrative reviewSchematic representation of the glycocalyx and its constituents. Syndecan and glypican are membrane-bound proteoglycans which carry chondroitin sulfate and heparan sulfate side chains. Syndecans are anchored to the plasma membrane via a single-span transmembrane protein and may therefore act as receptors. Glypicans are attached to the cell surface via a glycosylphosphatidylinositol (GPI) anchor. The glycocalyx is also comprised of secreted proteoglycans, such as perlecan, together with secreted glycosaminoglycans, such as hyaluronan. Note that this figure is not drawn to scaleBack to article page