Good neurological outcome despite very low regional cerebral oxygen saturation during resuscitation—a prospective preclinical trial in 29 patients

Table 1 Baseline characteristics

	Post ROSC	Pre ROSC	No ROSC
n	6	5	18
Age (years) (mean (sd))	68 (9)	66 (7)	61(14)
Sex male n (%)	6 (100)	4 (80)	14 (78)
APACHE score (median [IQR])	28 [20, 36]	37 [20, 40]	-
Shockable rhythm n (%)
Ventricular fibrillation	2 (33)	1 (20)	4 (22)
Asystolic	1 (17)	3 (60)	9 (50)
EMD	3 (50)	1 (20)	5 (27)
Time to ROSC (min) (median [IQR])	19 [11, 27]	12 [9, 16]	-
Total epinephrine dose (mg) (median [IQR])	2 [0.5, 4.25]	1 [1, 2]	7 [4, 9.5]
Haemoglobin (g/dl) (median [IQR])	12 [11, 14]	13 [12, 15]	-
Lactate (median [IQR])	29 [27, 45]	52 [43, 60]	-
Time on ventilator (hours) (median [IQR])	382 [164, 458]	212 [73, 388]	-
Length of ICU stay (days) (median [IQR])	17 [8, 20]	14 [3, 16]	-

Data are given as median and interquartile range (IQR) or absolute numbers and percent. ‘Post ROSC’ designates the group of patients in which NIRS was started shortly after ROSC, ‘pre ROSC’ designates the group with NIRS started during CPR and who achieved ROSC, ‘no ROSC’ the group with NIRS during CPR but no ROSC. APACHE Acute Physiology And Chronic Health Evaluation; OHCA out-of-hospital cardiac arrest; ROSC return of spontaneous circulation; ICU intensive care unit; EMD electromechanical dissociation; PaO₂ arterial oxygen partial pressure; SO₂ peripheral oxygen saturation; PaCO₂ arterial carbon dioxide partial pressure; FiO₂ fraction of inspired oxygen

ISSN: 1757-7241