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Table 3 Circulating inflammatory mediators in animals at baseline and after sea water drowning

From: Continuous venovenous hemofiltration decreases mortality and ameliorates acute lung injury in canine model of severe salt water drowning

  Baseline 15 min 120 min 240 min
IL-8
 Control 81.83 ± 34.22 106.8 ± 17* 161.1 ± 48.6* 174.3 ± 59.7*
 CVVH 87.67 ± 15.77 111.4 ± 8.3* 91.01 ± 17.5# 85.37 ± 23.6#
IL-6
 Control 219.4 ± 58.5 323.3 ± 96.1* 339.5 ± 106.5* 365.6 ± 119.5*
 CVVH 212.9 ± 33.0 378.5 ± 57.7* 249.9 ± 48.2 221.4 ± 27.8#
TNF-α
 Control 53.82 ± 16.81 79.53 ± 9.48* 76.17 ± 8.11* 89.78 ± 10.5*
 CVVH 50.34 ± 15.10 83.21 ± 8.95* 63.52 ± 11.3# 61.43 ± 17.6#
Endothelin
 Control 0.08 ± 0.05 N/A N/A 0.19 ± 0.11*
 CVVH 0.09 ± 0.04 N/A N/A 0.10 ± 0.04#
  1. Plasma IL-8, IL-6, TNF-α, and endothelin levels were from animals before and after involuntary intratracheal sea water infusion. All animals received mechanical ventilation after sea water infusion and then were randomly divided into control and CRRT group *p < 0.05, vs, the same group of animals before infusion (baseline); #p < 0.05,vs, animals in control group at the same time point