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Table 3 Circulating inflammatory mediators in animals at baseline and after sea water drowning

From: Continuous venovenous hemofiltration decreases mortality and ameliorates acute lung injury in canine model of severe salt water drowning

 

Baseline

15 min

120 min

240 min

IL-8

 Control

81.83 ± 34.22

106.8 ± 17*

161.1 ± 48.6*

174.3 ± 59.7*

 CVVH

87.67 ± 15.77

111.4 ± 8.3*

91.01 ± 17.5#

85.37 ± 23.6#

IL-6

 Control

219.4 ± 58.5

323.3 ± 96.1*

339.5 ± 106.5*

365.6 ± 119.5*

 CVVH

212.9 ± 33.0

378.5 ± 57.7*

249.9 ± 48.2

221.4 ± 27.8#

TNF-α

 Control

53.82 ± 16.81

79.53 ± 9.48*

76.17 ± 8.11*

89.78 ± 10.5*

 CVVH

50.34 ± 15.10

83.21 ± 8.95*

63.52 ± 11.3#

61.43 ± 17.6#

Endothelin

 Control

0.08 ± 0.05

N/A

N/A

0.19 ± 0.11*

 CVVH

0.09 ± 0.04

N/A

N/A

0.10 ± 0.04#

  1. Plasma IL-8, IL-6, TNF-α, and endothelin levels were from animals before and after involuntary intratracheal sea water infusion. All animals received mechanical ventilation after sea water infusion and then were randomly divided into control and CRRT group *p < 0.05, vs, the same group of animals before infusion (baseline); #p < 0.05,vs, animals in control group at the same time point