Table 2 Time course of plasma fibrinogen, PTI, aPTT, AT-III, platelet count, haemoglobin, WBC, CRP, IL-6 and PCT during 7 days after trauma in overall treatment group and control group

Treatment

1.58 (1.07–2.03)

2.33 (2.02–2.71)

4.15 (3.47–4.83)

5.51 (4.72–6.7)

6.12 (5.12–7.54)

6.55 (5.3–7.9)

6.8 (5.41–8.19)

6.99 (5.9–8.49)

n

242

242

238

239

231

227

224

207

Control

2.46 (2–2.98)

2.75 (2.25–3.25)

4.36 (3.77–5.32)

5.74 (4.74–6.74)

6.23 (5.07–7.64)

6.67 (5.25–7.9)

6.95 (5.56–8.24)

7 (5.59–8.45)

n

191

174

169

150

149

145

147

139

P-value

<0.0001

<0.0001

0.0034

0.2122

0.9996

0.6106

0.6995

0.6602

PTI (%)

 Treatment

66 (54–78.5)

60 (49–69)

60 (51–72)

73 (63–86)

82 (69–93)

84 (70–99)

87.5 (73–98)

87 (77–98)

  n

241

242

238

238

231

227

224

207

 Control

90 (78–101)

75 (64–85)

78 (64–87)

82 (70–94)

89 (76.5–99)

92 (79–101)

94 (84–104)

92 (81–103)

  n

192

175

169

150

149

145

147

140

 P-value

<0.0001

<0.0001

<0.0001

<0.0001

0.0009

0.0012

<0.0001

0.0038

aPTT (s)

 Treatment

30 (26.2–36.4)

39.5 (35.4–45.3)

39.7 (35.5–45.2)

38.3 (34.2–43.5)

36.1 (32–40.8)

34.3 (30.9–39.1)

33.2 (30–37.7)

32.3 (29.3–37.2)

  n

237

238

234

236

231

227

224

208

 Control

26.6 (24.1–28.9)

32.6 (30–36.6)

35 (31.6–38.3)

34.1 (31.5–38)

33 (29.7–36.3)

31.3 (28.9–35.5)

30.5 (28–34.4)

30 (27.4–33.3)

  n

192

175

168

149

149

145

147

140

 P-value

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

AT-III (%)

 Treatment

73 (61–86)

57 (46.3–66)

57 (46.8–68)

57.5 (48–68.8)

64 (53–75)

71 (60–86)

82 (64–96)

89.5 (75–103)

  n

103

204

182

164

152

131

119

116

 Control

88 (77–97)

74.5 (65.3–84)

75 (64–85)

76 (60.5–84)

85 (72–96.5)

90 (72.5–102.5)

98 (85–108.5)

100 (89.8–111.3)

  n

115

132

99

78

73

85

82

70

 P-value

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

0.0010

 Treatment

184 (143–230)

96 (64.8–134.3)

91.5 (64.8–117)

92 (65.5–120)

111.5 (76–144)

134 (94–174)

160 (116.8–209)

205 (158–266)

  n

241

242

242

241

238

237

238

229

 Control

222 (174–262)

158 (130–189.5)

141 (109–175)

143 (109–175)

160 (130–200.5)

184 (155–224.8)

209 (171.5–250)

240 (197–295)

  n

193

185

185

179

178

180

173

163

 P-value

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

 Treatment

110 (90–127)

90 (82–102)

90 (80–98)

88 (80–97)

90 (81–98)

90 (82–98)

91 (84–99)

90 (81–97)

  n

242

242

242

242

241

238

238

232

 Control

132 (118–142)

100 (90–111)

93 (84–109)

92 (82–106)

93 (84–104)

94 (85–105)

95 (86–106)

94 (87–106)

  n

193

187

190

184

184

185

178

166

 P-value

<0.0001

<0.0001

0.0004

0.0008

0.0103

0.0005

0.0013

<0.0001

 Treatment

13.1 (10–17.7)

7.1 (5.5–9.4)

8.6 (6.5–10.4)

7.9 (6.1–9.9)

7.4 (5.7–9.9)

7.9 (6.1–10.3)

9 (7.3–11.4)

10.2 (8–12.9)

  n

178

203

205

203

201

201

204

202

 Control

13.3 (10.8–17.3)

8.2 (6.4–9.9)

8.1 (6.7–9.9)

7.3 (6–9.6)

7.2 (5.6–9.3)

8 (6.3–9.9)

9.3 (7–11.1)

9.6 (7.3–11.7)

  n

129

131

129

128

127

128

127

125

 P-value

0.8283

0.0123

0.5443

0.4120

0.3542

0.9782

0.9680

0.0819

CRP (mg/l)

 Treatment

N/A

70 (39.5–95.5)

174 (135.5–224.5)

182 (128–236.5)

174 (104–228)

145 (88.8–213.3)

131.5 (80.5–207.3)

143 (89–211)

  n

217

197

194

206

202

198

185

 Control

N/A

58 (34.5–88.5)

147 (97.9–204)

145 (91–221.5)

130 (82.1–237.5)

113 (75.5–195)

94 (55.5–161)

92.9 (46.2–147.5)

  n

126

116

134

125

133

133

121

 P-value

0.0989

0.0015

0.0006

0.0788

0.0392

0.0010

<0.0001

IL-6 (pg/ml)

 Treatment

165 (86–422)

458 (209–1276)

261 (131–702)

175 (93–413)

130 (55–243)

133 (57–249)

116 (68–224)

79 (50–120)

  n

96

91

82

78

80

67

74

69

 Control

67 (28–144)

103 (58–284)

78 (40–240)

93 (43–258)

61 (31–122)

65 (30–134)

44 (25–82)

39 (21–77)

  n

103

61

51

50

52

49

57

47

 P-value

<0.0001

<0.0001

<0.0001

0.0012

0.0010

0.0005

<0.0001

0.0003

PCT (ng/ml)

 Treatment

N/A

2.2 (0.7–6)

2 (0.7–7.8)

1.3 (0.5–6)

1 (0.1–3)

0.7 (0.4–2.3)

0.5 (0.2–2)

0.5 (0.1–1.3)

  n

50

63

75

93

90

83

95

 Control

N/A

0.5 (0.2–1.5)

0.4 (0.1–1.8)

0.3 (0.2–1.3)

0.3 (0.2–1.3)

0.3 (0.1–0.7)

0.2 (0.1–0.5)

0.2 (0.1–0.4)

  n

53

60

53

62

62

65

66

 P-value

<0.0001

<0.0001

0.0001

0.0607

<0.0001

<0.0001

0.0006