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Table 2 Time course of plasma fibrinogen, PTI, aPTT, AT-III, platelet count, haemoglobin, WBC, CRP, IL-6 and PCT during 7 days after trauma in overall treatment group and control group

From: Fibrinogen levels in trauma patients during the first seven days after fibrinogen concentrate therapy: a retrospective study

  ER Day 1 Day 2 Day 3 Day 4 Day 5 Day 6 Day 7
Fibrinogen (g/l)
Treatment 1.58 (1.07–2.03) 2.33 (2.02–2.71) 4.15 (3.47–4.83) 5.51 (4.72–6.7) 6.12 (5.12–7.54) 6.55 (5.3–7.9) 6.8 (5.41–8.19) 6.99 (5.9–8.49)
n 242 242 238 239 231 227 224 207
Control 2.46 (2–2.98) 2.75 (2.25–3.25) 4.36 (3.77–5.32) 5.74 (4.74–6.74) 6.23 (5.07–7.64) 6.67 (5.25–7.9) 6.95 (5.56–8.24) 7 (5.59–8.45)
n 191 174 169 150 149 145 147 139
P-value <0.0001 <0.0001 0.0034 0.2122 0.9996 0.6106 0.6995 0.6602
PTI (%)         
 Treatment 66 (54–78.5) 60 (49–69) 60 (51–72) 73 (63–86) 82 (69–93) 84 (70–99) 87.5 (73–98) 87 (77–98)
n 241 242 238 238 231 227 224 207
 Control 90 (78–101) 75 (64–85) 78 (64–87) 82 (70–94) 89 (76.5–99) 92 (79–101) 94 (84–104) 92 (81–103)
n 192 175 169 150 149 145 147 140
 P-value <0.0001 <0.0001 <0.0001 <0.0001 0.0009 0.0012 <0.0001 0.0038
aPTT (s)         
 Treatment 30 (26.2–36.4) 39.5 (35.4–45.3) 39.7 (35.5–45.2) 38.3 (34.2–43.5) 36.1 (32–40.8) 34.3 (30.9–39.1) 33.2 (30–37.7) 32.3 (29.3–37.2)
n 237 238 234 236 231 227 224 208
 Control 26.6 (24.1–28.9) 32.6 (30–36.6) 35 (31.6–38.3) 34.1 (31.5–38) 33 (29.7–36.3) 31.3 (28.9–35.5) 30.5 (28–34.4) 30 (27.4–33.3)
n 192 175 168 149 149 145 147 140
 P-value <0.0001 <0.0001 <0.0001 <0.0001 <0.0001 <0.0001 <0.0001 <0.0001
AT-III (%)         
 Treatment 73 (61–86) 57 (46.3–66) 57 (46.8–68) 57.5 (48–68.8) 64 (53–75) 71 (60–86) 82 (64–96) 89.5 (75–103)
n 103 204 182 164 152 131 119 116
 Control 88 (77–97) 74.5 (65.3–84) 75 (64–85) 76 (60.5–84) 85 (72–96.5) 90 (72.5–102.5) 98 (85–108.5) 100 (89.8–111.3)
n 115 132 99 78 73 85 82 70
 P-value <0.0001 <0.0001 <0.0001 <0.0001 <0.0001 <0.0001 <0.0001 0.0010
Platelet count (×109/l)        
 Treatment 184 (143–230) 96 (64.8–134.3) 91.5 (64.8–117) 92 (65.5–120) 111.5 (76–144) 134 (94–174) 160 (116.8–209) 205 (158–266)
n 241 242 242 241 238 237 238 229
 Control 222 (174–262) 158 (130–189.5) 141 (109–175) 143 (109–175) 160 (130–200.5) 184 (155–224.8) 209 (171.5–250) 240 (197–295)
n 193 185 185 179 178 180 173 163
 P-value <0.0001 <0.0001 <0.0001 <0.0001 <0.0001 <0.0001 <0.0001 <0.0001
Haemoglobin (g/l)        
 Treatment 110 (90–127) 90 (82–102) 90 (80–98) 88 (80–97) 90 (81–98) 90 (82–98) 91 (84–99) 90 (81–97)
n 242 242 242 242 241 238 238 232
 Control 132 (118–142) 100 (90–111) 93 (84–109) 92 (82–106) 93 (84–104) 94 (85–105) 95 (86–106) 94 (87–106)
n 193 187 190 184 184 185 178 166
 P-value <0.0001 <0.0001 0.0004 0.0008 0.0103 0.0005 0.0013 <0.0001
White Blood Cell count (×109/l)       
 Treatment 13.1 (10–17.7) 7.1 (5.5–9.4) 8.6 (6.5–10.4) 7.9 (6.1–9.9) 7.4 (5.7–9.9) 7.9 (6.1–10.3) 9 (7.3–11.4) 10.2 (8–12.9)
n 178 203 205 203 201 201 204 202
 Control 13.3 (10.8–17.3) 8.2 (6.4–9.9) 8.1 (6.7–9.9) 7.3 (6–9.6) 7.2 (5.6–9.3) 8 (6.3–9.9) 9.3 (7–11.1) 9.6 (7.3–11.7)
n 129 131 129 128 127 128 127 125
 P-value 0.8283 0.0123 0.5443 0.4120 0.3542 0.9782 0.9680 0.0819
CRP (mg/l)         
 Treatment N/A 70 (39.5–95.5) 174 (135.5–224.5) 182 (128–236.5) 174 (104–228) 145 (88.8–213.3) 131.5 (80.5–207.3) 143 (89–211)
n   217 197 194 206 202 198 185
 Control N/A 58 (34.5–88.5) 147 (97.9–204) 145 (91–221.5) 130 (82.1–237.5) 113 (75.5–195) 94 (55.5–161) 92.9 (46.2–147.5)
n   126 116 134 125 133 133 121
 P-value   0.0989 0.0015 0.0006 0.0788 0.0392 0.0010 <0.0001
IL-6 (pg/ml)         
 Treatment 165 (86–422) 458 (209–1276) 261 (131–702) 175 (93–413) 130 (55–243) 133 (57–249) 116 (68–224) 79 (50–120)
n 96 91 82 78 80 67 74 69
 Control 67 (28–144) 103 (58–284) 78 (40–240) 93 (43–258) 61 (31–122) 65 (30–134) 44 (25–82) 39 (21–77)
n 103 61 51 50 52 49 57 47
 P-value <0.0001 <0.0001 <0.0001 0.0012 0.0010 0.0005 <0.0001 0.0003
PCT (ng/ml)         
 Treatment N/A 2.2 (0.7–6) 2 (0.7–7.8) 1.3 (0.5–6) 1 (0.1–3) 0.7 (0.4–2.3) 0.5 (0.2–2) 0.5 (0.1–1.3)
n   50 63 75 93 90 83 95
 Control N/A 0.5 (0.2–1.5) 0.4 (0.1–1.8) 0.3 (0.2–1.3) 0.3 (0.2–1.3) 0.3 (0.1–0.7) 0.2 (0.1–0.5) 0.2 (0.1–0.4)
n   53 60 53 62 62 65 66
 P-value   <0.0001 <0.0001 0.0001 0.0607 <0.0001 <0.0001 0.0006
  1. aPTT activated partial thromboplastin time, AT-III antithrombin III, CRP C-reactive protein, ER emergency room, IL-6 interleukin 6, N/A not available, PCT procalcitonin, PTI prothrombin time index
  2. P < 0.05 was considered significant
  3. Data presented as median (interquartile range); n = available values