Fig. 3

Time course of interleukin-6 (a) C-reactive protein (b) and procalcitonin (c) during the first 7 days after trauma categorized according to the dose of fibrinogen concentrate administered. Control (white), 1–4 g FC (yellow), 5–9 g FC (orange), ≥10 g FC (red). Data shown are median, interquartile range and range. Dots represent outliers. ER, values on admission to the emergency room; not indicated = not significant; *P < 0.05; **P < 0.01; ***P < 0.001; in the Newman-Keuls multiple comparisons between all four groups. C- reactive protein and procalcitonin were not measured on admission to the ER