|  | 0–6 h | 6–72 h | 0–72 h | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Author | Â | EGDT | Usual care | P | EGDT | Usual care | P | EGDT | Usual care | P |
Wang [45] | Intravenous fluids (ml) | 4895 ± 210a | 2340 ± 95a | 0.01 | NA | NA | NA | NA | NA | NA |
Rivers [7] | Intravenous fluids (ml) | 4981 ± 2984a | 3499 ± 2438a | 0.001 | 8625 ± 5162a | 10602 ± 6216a | 0.01 | 13443 ± 6390a | 13358 ± 7729a | 0.73 |
 | Vasopressor use | 32/117 | 36/119 | 0.62 | 34/117 | 51/119 | 0.03 | 43/117 | 61/119 | 0.02 |
 | Dobutamine use | 16/117 | 1/119 | 0.001 | 17/117 | 10/119 | 0.14 | 18/117 | 11/119 | 0.15 |
 | Blood transfusion | 75/117 | 22/119 | 0.001 | 13/117 | 39/119 | 0.001 | 80/117 | 53/119 | 0.001 |
ProCESS [6] | Intravenous fluids (ml) | 2805 ± 1957a | 2279 ± 1881a | 0.0001 | 4458 ± 3878a | 4354 ± 3882a | 0.08 | 7253 ± 4605a | 6633 ± 4560a | 0.0001 |
 | Vasopressor use | 241/439 | 201/456 | 0.003 | 209/439 | 197/456 | 0.38 | 265/439 | 245/456 | 0.05 |
 | Dobutamine use | 35/439 | 4/456 | 0.0001 | 19/439 | 10/456 | 0.08 | 41/439 | 13/456 | 0.0001 |
 | Blood transfusion | 63/439 | 34/456 | 0.001 | 87/439 | 82/456 | 0.54 | 120/439 | 102/456 | 0.22 |
ARISE [30] | Intravenous fluids (ml) | 1964 ± 1415a | 1713 ± 1401a | 0.001 | 4274 ± 3071a | 4382 ± 3136a | 0.51 | NA | NA | NA |
 | Vasopressor use | 528/793 | 461/798 | 0.001 | 460/782 | 401/778 | 0.004 | NA | NA | NA |
 | Dobutamine use | 122/793 | 21/798 | 0.001 | 74/782 | 39/788 | 0.001 | NA | NA | NA |
 | Blood transfusion | 108/793 | 56/798 | 0.001 | 86/782 | 92/778 | 0.61 | NA | NA | NA |
ProMISe [31] | Intravenous fluids (ml) | 2226 ± 1443a | 2022 ± 1271 | NA | 4215 ± 3068a | 4366 ± 3114 | NA | 5946 ± 3740a | 5844 ± 3651a | NA |
 | Vasopressor use | 332/623 | 291/625 | NA | 349/603 | 317/603 | NA | 377/623 | 344/625 | NA |
 | Dobut mine use | 113/623 | 24/625 | NA | 107/603 | 39/603 | NA | 139/623 | 44/625 | NA |
 | Blood transfusion | 55/623 | 24/625 | NA | 76/603 | 51/603 | NA | 107/623 | 65/625 | NA |