Skip to main content

Table 4 Resuscitation and processes of care from baseline to 72 h

From: Early goal-directed resuscitation for patients with severe sepsis and septic shock: a meta-analysis and trial sequential analysis

  

0–6 h

6–72 h

0–72 h

Author

 

EGDT

Usual care

P

EGDT

Usual care

P

EGDT

Usual care

P

Wang [45]

Intravenous fluids (ml)

4895 ± 210a

2340 ± 95a

0.01

NA

NA

NA

NA

NA

NA

Rivers [7]

Intravenous fluids (ml)

4981 ± 2984a

3499 ± 2438a

0.001

8625 ± 5162a

10602 ± 6216a

0.01

13443 ± 6390a

13358 ± 7729a

0.73

 

Vasopressor use

32/117

36/119

0.62

34/117

51/119

0.03

43/117

61/119

0.02

 

Dobutamine use

16/117

1/119

0.001

17/117

10/119

0.14

18/117

11/119

0.15

 

Blood transfusion

75/117

22/119

0.001

13/117

39/119

0.001

80/117

53/119

0.001

ProCESS [6]

Intravenous fluids (ml)

2805 ± 1957a

2279 ± 1881a

0.0001

4458 ± 3878a

4354 ± 3882a

0.08

7253 ± 4605a

6633 ± 4560a

0.0001

 

Vasopressor use

241/439

201/456

0.003

209/439

197/456

0.38

265/439

245/456

0.05

 

Dobutamine use

35/439

4/456

0.0001

19/439

10/456

0.08

41/439

13/456

0.0001

 

Blood transfusion

63/439

34/456

0.001

87/439

82/456

0.54

120/439

102/456

0.22

ARISE [30]

Intravenous fluids (ml)

1964 ± 1415a

1713 ± 1401a

0.001

4274 ± 3071a

4382 ± 3136a

0.51

NA

NA

NA

 

Vasopressor use

528/793

461/798

0.001

460/782

401/778

0.004

NA

NA

NA

 

Dobutamine use

122/793

21/798

0.001

74/782

39/788

0.001

NA

NA

NA

 

Blood transfusion

108/793

56/798

0.001

86/782

92/778

0.61

NA

NA

NA

ProMISe [31]

Intravenous fluids (ml)

2226 ± 1443a

2022 ± 1271

NA

4215 ± 3068a

4366 ± 3114

NA

5946 ± 3740a

5844 ± 3651a

NA

 

Vasopressor use

332/623

291/625

NA

349/603

317/603

NA

377/623

344/625

NA

 

Dobut mine use

113/623

24/625

NA

107/603

39/603

NA

139/623

44/625

NA

 

Blood transfusion

55/623

24/625

NA

76/603

51/603

NA

107/623

65/625

NA

  1. NA no available, P P value
  2. amean ± standard deviation