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Table 1 Characteristics of included studies in the meta-analysis

From: Early goal-directed resuscitation for patients with severe sepsis and septic shock: a meta-analysis and trial sequential analysis

Study/Year Country Setting No. of patients Resuscitation goals Outcomea
Intervention Control Intervention Control
Rivers [7]/2001 America Eemergency department 130 133 SvO2 ≥ 70 % CVP 8–12 mmHg MAP 65–90 mmHg Urine volume ≥0.5 ml/kg/h CVP 8–12 mmHg
MAP 65–90 mmHg
Urine volume ≥0.5 ml/kg/h
Hospital mortality
Wang [45]/2006 China ICU 16 17 SvO2 ≥ 70 % CVP 8–12 mmHg MAP ≥65 mmHg Urine volume ≥0.5 ml/kg/h MAP ≥65 mmHg Urine volume ≥0.5 ml/kg/h 14 days mortality
Yan [46]/2010 China ICU 157 146 ScvO2 ≥ 70 % CVP 8–12 mmHg SBP >90 mmHg MAP ≥65 mmHg Urine volume ≥0.5 ml/kg/h CVP 8–12 mmHg
SBP >90 mmHg
MAP ≥65 mmHg Urine volume ≥0.5 ml/kg/h
ICU mortality
ProCESS [6]/2014 America Eemergency department 439 456 ScvO2 ≥ 70 % CVP 8–12 mmHg MAP 65–90 mmHg Urine volume ≥0.5 ml/kg/h Usual care Hospital mortality
ARISE [30]/2014 Australia/New Zealand Eemergency department 793 798 SpO2 ≥ 93 % ScvO2 ≥ 70 % CVP (Self-ventilation) >8 CVP (Non-invasive/invasive MV) >12 mmHg
MAP 65–90 mmHg Urine volume ≥0.6 ml/kg/h Haematocrit ≥30 %
Usual care 90 days mortality
ProMISe [31]/2015 UK Eemergency department 625 626 ScvO2 ≥ 70 % CVP 8–12 mmHg MAP 65–90 mmHg Urine volume ≥0.5 ml/kg/h Usual care 90 days mortality
  1. CVP central venous pressure, MAP mean arterial pressure, ScvO 2 central venous oxygen saturation
  2. aprimary outcome