Table 1 Characteristics of included studies in the meta-analysis
Study/Year | Country | Setting | No. of patients | Resuscitation goals | Outcomea | ||
|---|---|---|---|---|---|---|---|
Intervention | Control | Intervention | Control | ||||
Rivers [7]/2001 | America | Eemergency department | 130 | 133 | SvO2 ≥ 70 % CVP 8–12 mmHg MAP 65–90 mmHg Urine volume ≥0.5 ml/kg/h | CVP 8–12 mmHg MAP 65–90 mmHg Urine volume ≥0.5 ml/kg/h | Hospital mortality |
Wang [45]/2006 | China | ICU | 16 | 17 | SvO2 ≥ 70 % CVP 8–12 mmHg MAP ≥65 mmHg Urine volume ≥0.5 ml/kg/h | MAP ≥65 mmHg Urine volume ≥0.5 ml/kg/h | 14 days mortality |
Yan [46]/2010 | China | ICU | 157 | 146 | ScvO2 ≥ 70 % CVP 8–12 mmHg SBP >90 mmHg MAP ≥65 mmHg Urine volume ≥0.5 ml/kg/h | CVP 8–12 mmHg SBP >90 mmHg MAP ≥65 mmHg Urine volume ≥0.5 ml/kg/h | ICU mortality |
ProCESS [6]/2014 | America | Eemergency department | 439 | 456 | ScvO2 ≥ 70 % CVP 8–12 mmHg MAP 65–90 mmHg Urine volume ≥0.5 ml/kg/h | Usual care | Hospital mortality |
ARISE [30]/2014 | Australia/New Zealand | Eemergency department | 793 | 798 | SpO2 ≥ 93 % ScvO2 ≥ 70 % CVP (Self-ventilation) >8 CVP (Non-invasive/invasive MV) >12 mmHg MAP 65–90 mmHg Urine volume ≥0.6 ml/kg/h Haematocrit ≥30 % | Usual care | 90 days mortality |
ProMISe [31]/2015 | UK | Eemergency department | 625 | 626 | ScvO2 ≥ 70 % CVP 8–12 mmHg MAP 65–90 mmHg Urine volume ≥0.5 ml/kg/h | Usual care | 90 days mortality |