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Fig. 4 | Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

Fig. 4

From: Early goal-directed resuscitation for patients with severe sepsis and septic shock: a meta-analysis and trial sequential analysis

Fig. 4

Trial sequential analysis of all-cause mortality in patients with severe sepsis and septic shock. Trial sequential analyses assessing the effect of early goal-direced therapy on all-cause mortality in 6 studies. The diversity-adjusted required information size was based on a relative risk reduction of 20; an alpha of 5; a beta of 2 and an event proportion of 25.7 % in the control arm. The blue cumulative z curve was constructed using a random effects model

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