Cytokine gene polymorphism | Genotype/Allele | Survivors | Non-survivors | p Value | OR (95 % CI) |
---|---|---|---|---|---|
n (%) | n (%) | ||||
n = 77 | n = 37 | ||||
IL-1β(−511) | CC | 34(44.1) | 9(24.4) | 1 | |
CT | 27(35) | 20(54) | 0.03 | 2.7(1.0–7.1) | |
TT | 16(20.9) | 8(21.6) | 1.8(0.61–5.8) | ||
C | 95(83.3) | 38(51.3) | 0.13 | 1 | |
T | 59(16.7) | 36(49.7) | 1.5(0.83–2.7) | ||
IL-1R(pst I 1970) | CC | 29(37.6) | 9(24.3) | 1 | |
CT | 41(53.2) | 17(45.9) | 0.02 | 1.3(0.52–3.4) | |
TT | 7(9.0) | 11(29.8) | 5.0(1.5–16.9) | ||
C | 99(64.2) | 35(47.3) | 0.01 | 1 | |
T | 55(35.8) | 39(52.7) | 2.0(1.0–3.6) | ||
IL-4R(+1902) | AA | 51(66.2) | 17(46) | 1 | |
GA | 22(28.6) | 16(43) | 0.08 | 2.1(0.93–5.0) | |
GG | 4(5.2) | 4(11) | 3(0.67–13.3) | ||
A | 124(80.5) | 15(20.2) | 0.001 | 1 | |
G | 30(19.5) | 59(79.8) | 16.2(7.7–34.7) | ||
IL-12(−1188) | CC | 10(12.9) | 3(8.1) | 1 | |
CA | 25(32.4) | 9(24.3) | 0.49 | 1.2(0.26–5.3) | |
AA | 42(54.7) | 25(67.6) | 1.9(0.49–7.9) | ||
C | 45(29.2) | 47(20.2) | 0.001 | 1 | |
A | 109(70.8) | 27(79.8) | 0.23(0.12–0.44) | ||
TGF-β(codon25) | CC | 61(79.2) | 26(70.27) | 1 | |
CG | 14(18.2) | 8(21.62) | 0.04 | 1.3(0.50–3.6) | |
GG | 2(2.6) | 3(8.1) | 3.5(0.55–22.3) | ||
C | 136(88.3) | 60(81.1) | 0.14 | 1 | |
G | 18(11.7) | 14(18.9) | 0.56(0.24–1.3) |