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Table 7 Comparison of genotypic and allelic frequency in non-survivors and survivors patients

From: Clinical relevance of single nucleotide polymorphisms within the 13 cytokine genes in North Indian trauma hemorrhagic shock patients

Cytokine gene polymorphism

Genotype/Allele

Survivors

Non-survivors

p Value

OR (95 % CI)

n (%)

n (%)

n = 77

n = 37

IL-1β(−511)

CC

34(44.1)

9(24.4)

 

1

CT

27(35)

20(54)

0.03

2.7(1.0–7.1)

TT

16(20.9)

8(21.6)

 

1.8(0.61–5.8)

C

95(83.3)

38(51.3)

0.13

1

T

59(16.7)

36(49.7)

 

1.5(0.83–2.7)

IL-1R(pst I 1970)

CC

29(37.6)

9(24.3)

 

1

CT

41(53.2)

17(45.9)

0.02

1.3(0.52–3.4)

TT

7(9.0)

11(29.8)

 

5.0(1.5–16.9)

C

99(64.2)

35(47.3)

0.01

1

T

55(35.8)

39(52.7)

 

2.0(1.0–3.6)

IL-4R(+1902)

AA

51(66.2)

17(46)

 

1

GA

22(28.6)

16(43)

0.08

2.1(0.93–5.0)

GG

4(5.2)

4(11)

 

3(0.67–13.3)

A

124(80.5)

15(20.2)

0.001

1

G

30(19.5)

59(79.8)

 

16.2(7.7–34.7)

IL-12(−1188)

CC

10(12.9)

3(8.1)

 

1

CA

25(32.4)

9(24.3)

0.49

1.2(0.26–5.3)

AA

42(54.7)

25(67.6)

 

1.9(0.49–7.9)

C

45(29.2)

47(20.2)

0.001

1

A

109(70.8)

27(79.8)

 

0.23(0.12–0.44)

TGF-β(codon25)

CC

61(79.2)

26(70.27)

 

1

CG

14(18.2)

8(21.62)

0.04

1.3(0.50–3.6)

GG

2(2.6)

3(8.1)

 

3.5(0.55–22.3)

C

136(88.3)

60(81.1)

0.14

1

G

18(11.7)

14(18.9)

 

0.56(0.24–1.3)