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Table 5 Distribution of genotypes in non-sepsis and sepsis patients using multivariate logistic regression analysis

From: Clinical relevance of single nucleotide polymorphisms within the 13 cytokine genes in North Indian trauma hemorrhagic shock patients

Cytokine gene polymorphism

Genotype

Non-sepsis

Sepsis

Unadjusted odds ratio

Adjusted odds ratio

f (%)

f (%)

OR (95 % C.I)

p value

OR (95 % C.I)

p value

n = 89

n = 25

IL-α(−889)

CC

45(50.56)

21(84)

1

 

1

 

TC

32(35.96)

3(12)

0.20(0.05–0.73)

0.01

0.21(0.05–0.79)

0.02

TT

12(13.48)

1(4)

0.17(0.02–1.4)

0.10

0.25(0.02–2.1)

0.20

TNF-α(−238)

GG

78(87.7)

19(76)

1

 

1

 

GA

10(11.2)

4(16)

0.2 (0.13–2.8)

0.2

0.19(0.01–3.1)

0.2

AA

1(1.1)

2(8)

0.12(0.01–1.4)

0.09

0.09(0.007–1.3)

0.08

TNF-α(−308

AA

3(3.3)

2(8)

1

 

1

 

GA

17(19.1)

1(4)

0.08(0.05–1.3)

0.07

0.10(0.006–1.6)

0.10

GG

69(77.6)

22(88)

0.47(0.07–3.0)

0.43

0.64(0.09–4.6)

0.66

IL-4(−1098)

TT

66(74.1)

12(48)

1

 

1

 

TG

21(23.6)

9(36)

2.3(0.87–6.3)

0.09

1.8(0.47–7.5)

0.36

GG

2(2.3)

4(16)

11(1.8–66.9)

0.009

6.1(0.58–64)

0.12

IL-10(−1082)

GG

5(5.7)

4(16)

1

 

1

 

GA

33(37)

2(8)

0.07(0.01–0.52)

0.01

0.36(0.03–3.5)

0.38

AA

51(57.3)

19(76)

0.65(0.11–1.9)

0.29

1.9(0.33–11.5)

0.45

  1. n (%) = number of subjects (expressed as percentage),OR = odds ratio, CI = class intervals
  2. Adjusted odds ratio for ISS, SOFA score and gender