Skip to main content

Advertisement

Table 5 Distribution of genotypes in non-sepsis and sepsis patients using multivariate logistic regression analysis

From: Clinical relevance of single nucleotide polymorphisms within the 13 cytokine genes in North Indian trauma hemorrhagic shock patients

Cytokine gene polymorphism Genotype Non-sepsis Sepsis Unadjusted odds ratio Adjusted odds ratio
f (%) f (%) OR (95 % C.I) p value OR (95 % C.I) p value
n = 89 n = 25
IL-α(−889) CC 45(50.56) 21(84) 1   1  
TC 32(35.96) 3(12) 0.20(0.05–0.73) 0.01 0.21(0.05–0.79) 0.02
TT 12(13.48) 1(4) 0.17(0.02–1.4) 0.10 0.25(0.02–2.1) 0.20
TNF-α(−238) GG 78(87.7) 19(76) 1   1  
GA 10(11.2) 4(16) 0.2 (0.13–2.8) 0.2 0.19(0.01–3.1) 0.2
AA 1(1.1) 2(8) 0.12(0.01–1.4) 0.09 0.09(0.007–1.3) 0.08
TNF-α(−308 AA 3(3.3) 2(8) 1   1  
GA 17(19.1) 1(4) 0.08(0.05–1.3) 0.07 0.10(0.006–1.6) 0.10
GG 69(77.6) 22(88) 0.47(0.07–3.0) 0.43 0.64(0.09–4.6) 0.66
IL-4(−1098) TT 66(74.1) 12(48) 1   1  
TG 21(23.6) 9(36) 2.3(0.87–6.3) 0.09 1.8(0.47–7.5) 0.36
GG 2(2.3) 4(16) 11(1.8–66.9) 0.009 6.1(0.58–64) 0.12
IL-10(−1082) GG 5(5.7) 4(16) 1   1  
GA 33(37) 2(8) 0.07(0.01–0.52) 0.01 0.36(0.03–3.5) 0.38
AA 51(57.3) 19(76) 0.65(0.11–1.9) 0.29 1.9(0.33–11.5) 0.45
  1. n (%) = number of subjects (expressed as percentage),OR = odds ratio, CI = class intervals
  2. Adjusted odds ratio for ISS, SOFA score and gender