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Table 6 Summary of Findings (GRADE): Lateral position compared to supine position for patients with reduced consciousness

From: Is the supine position associated with loss of airway patency in unconscious trauma patients? A systematic review and meta-analysis

Outcomes Illustrative comparative risks (95% CI) № of participants Quality of the evidence
Assumed risk Corresponding risk (Studies) (GRADE)
Supine position Lateral position
AHI - Adults with sleep apnea The median AHI (episodes/h) in the control group was 52.4 The mean AHI (episodes/h) in the intervention group was 22.8 fewer (29.1 fewer to16.6 fewer) 2780 (20 observational comparisons) 1
AHI - Adults before and after surgery The median AHI (episodes/h) in the control group was 26.0 The mean AHI (episodes/h) in the intervention group was 10.4 fewer (15.2 fewer to 5.6 fewer) 1448 (3 observational comparisons)
AHI - Patients with stroke/TIA The median AHI (episodes/h) in the control group was 23 The mean AHI (episodes/h) in the intervention group was 13.9 fewer (20.9 fewer to 6.8 fewer) 196 (2 observational studies)
AHI - Infants and small children The median AHI (episodes/h) in the control group was 2.5 The mean AHI (episodes/h) in the intervention group was 0.74 more (0.6 fewer to 2.08 more) 190 (9 observational comparisons)
  1. 1. Three more studies were not included: Not sufficient data for analysis given.
  2. 2. Studies in which patients were their own controls.
  3. 3. In a number of the studies there was unclear bias regarding representativity, but internal validity was intact so we did not downgrade for this.
  4. 4. Unexplained heterogeneity regarding the size of effect, but a clear effect estimate in favor of the intervention. We upgraded for large effect.
  5. 5. Indirectness in population.
  6. 6. Small cumulative sample size, but clear benefit.
  7. 7. Unexplained heterogeneity regarding direction of effect, I2=90%, we downgraded for this uncertainty.
  8. 8. CI 95% includes both benefit and harm, but clinically insignificant difference.