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Table 1 Studies evaluating the effect of a massive transfusion protocol in paediatric trauma patients

From: Transfusion therapy in paediatric trauma patients: a review of the literature

Author

No.

Type of study

FFP:RBC ratio high vs. low

PLT:RBC ratio high vs. low

Mortality high vs. low

Comments

Hendrickson et al. [3]

102

RC vs. PI

1:1.8 vs. 1:3.6

1:6.7 vs. 1:5.9

38% vs. 23% (p=0.35)

The majority of pre-MTP (80%) and MTP (72%) patients had at least one abnormal coagulation value on presentation to the ED1

Chidester et al. [20]

55

PI

1:3 vs. 1:3

NR

45% vs. 45% (p value NR)

Early coagulopathy2 initiated MTP. 4 thrombo-embolic events in the non-MTP group vs. 0 in the MTP group

Dressler et al. [56]

1

Case

4:4

5:4

NA

 

Pickett et al. [57]

1

Case

3:6

5:6

NA

 

Paterson et al. [58]

1

Case

1:1.5

1:1.5

NA

 
  1. 1Abnormal coagulation parameters defined as prothrombin time (PT) >15.9 sec, partial thromboplastin time (PTT) >42.1 sec, fibrinogen <180 mg/dl or platelets < 185 × 109/l.
  2. 2Early coagulopathy defined by a PTT > 36 seconds.
  3. RC: retrospective cohort; PI: prospective intervention; Case: case report; FFP: fresh frozen plasma; RBC: red blood cells; PLT: platelet concentrate; NR: not reported; NA: not applicable; MTP: massive transfusion protocol; ED: emergency department.