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Table 1 Studies evaluating the effect of a massive transfusion protocol in paediatric trauma patients

From: Transfusion therapy in paediatric trauma patients: a review of the literature

Author No. Type of study FFP:RBC ratio high vs. low PLT:RBC ratio high vs. low Mortality high vs. low Comments
Hendrickson et al. [3] 102 RC vs. PI 1:1.8 vs. 1:3.6 1:6.7 vs. 1:5.9 38% vs. 23% (p=0.35) The majority of pre-MTP (80%) and MTP (72%) patients had at least one abnormal coagulation value on presentation to the ED1
Chidester et al. [20] 55 PI 1:3 vs. 1:3 NR 45% vs. 45% (p value NR) Early coagulopathy2 initiated MTP. 4 thrombo-embolic events in the non-MTP group vs. 0 in the MTP group
Dressler et al. [56] 1 Case 4:4 5:4 NA  
Pickett et al. [57] 1 Case 3:6 5:6 NA  
Paterson et al. [58] 1 Case 1:1.5 1:1.5 NA  
  1. 1Abnormal coagulation parameters defined as prothrombin time (PT) >15.9 sec, partial thromboplastin time (PTT) >42.1 sec, fibrinogen <180 mg/dl or platelets < 185 × 109/l.
  2. 2Early coagulopathy defined by a PTT > 36 seconds.
  3. RC: retrospective cohort; PI: prospective intervention; Case: case report; FFP: fresh frozen plasma; RBC: red blood cells; PLT: platelet concentrate; NR: not reported; NA: not applicable; MTP: massive transfusion protocol; ED: emergency department.