Mild TBI group (n = 24,905) | Control group (n = 719,811) | ||
---|---|---|---|
Variables | Hazard ratio | 95% confidence interval | P-value |
Mild TBI | 1.46 | 1.33–1.62 | <0.001 |
Male | 1.47 | 1.41–1.53 | <0.001 |
Patient age | 1.07 | 1.06–1.07 | <0.001 |
Socioeconomic status | |||
Low | 1 | -- | -- |
Moderate | 0.80 | 0.76–0.84 | <0.001 |
High | 0.49 | 0.44–0.55 | <0.001 |
Urbanization level | |||
Urban | 1 | -- | -- |
Suburban | 1.17 | 1.11–1.23 | <0.001 |
Rural | 1.39 | 1.32–1.48 | <0.001 |
Diabetes | 1.57 | 1.49–1.65 | <0.001 |
Hypertension | 1.77 | 1.68–1.85 | <0.001 |
Coronary artery disease | 1.43 | 1.37–1.50 | <0.001 |
Hyperlipidemia | 0.89 | 0.84–0.93 | <0.001 |
History of alcohol intoxication | 1.46 | 1.20–1.76 | 0.001 |
Malignancies | 1.06 | 0.99–1.14 | 0.122 |
Charlson Comorbidity Index score | |||
0 | 1 | -- | -- |
1 | 1.37 | 1.29–1.45 | <0.001 |
≥ 2 | 1.57 | 1.47–1.67 | <0.001 |
Heart failure | 1.11 | 1.03–1.21 | 0.008 |
Atrial fibrillation | 1.42 | 1.26–1.60 | <0.001 |
Smoking | 0.99 | 0.79–1.24 | 0.937 |
Obesity | 1.13 | 0.83–1.56 | 0.433 |
Epilepsy | 2.13 | 1.85–2.45 | <0.001 |
Peripheral artery disease | 1.06 | 0.93–1.21 | 0.384 |