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Table 3 Diagnostic test for CRP, temperature and SIRS

From: How do bacteraemic patients present to the emergency department and what is the diagnostic validity of the clinical parameters; temperature, C-reactive protein and systemic inflammatory response syndrome?

  Non-bacteremic Patients *n (%) Bacteremic Patients n (%) Sensitivity (95% CI) Specificity (95% CI) PPV (95% CI) NPV (95% CI) + LR (95% CI) - LR (95% CI)
Temperature > 38.0°C 1879 (88.5) 245 (11.5) 64.3 (59.3–69.1) 80.8 (80.0–81.6) 11.5 (10.2–13.0) 98.3 (98.0–98.6) 3.4 (3.1–3.6) 0.4 (0.4–0.5)
CRP ≥ 100 mg/dL 2064 (88.2) 277 (11.8) 67.4 (62.6–71.9) 79.0 (78.2–79.8) 11.8 (10.6–13.2) 98.3 (98.0–98.6) 3.2 (3.0–3.5) 0.4 (0.3–0.5)
SIRS 3546 (92.2) 301 (7.8) 72.0 (67.4–76.3) 69.4 (68.5–70.2) 7.8 (6.9–8.7) 98.6 (98.3–98.8) 2.4 (2.2–2.5) 0.4 (0.3–0.5)
Combination test 7140 (94.7) 397 (5.3) 95.0 (92.4–96.9) 38.3 (37.4–39.2) 5.3 (4.8–5.8) 99.5 (99.3–99-7) 1.5 (1.5–1.6) 0.1 (0.1–0.2)
  1. Results of the diagnostic tests for the clinical parameters temperature, C-reactive protein (CRP), the Systemic Inflammatory Response Syndrome (SIRS) and the Combination test (Temperature >38°C, or a CRP > 100 mg/dL or ≥2 SIRS criteria). Analysed in all adult Medical Emergency Department patients (n = 11,988). PPV: Positive Predictive Value. NPV: Negative Predictive Value. +LR: Positive Likelihood Ratio, −LR: Negative Likelihood Ratio. CI: 95% Confidence Interval.
  2. *: Non blood-cultured and blood cultured non-bacteraemic patients. The percent is presented horizontally.