Impact of fibrinogen concentrate alone or with prothrombin complex concentrate (+/− fresh frozen plasma) on plasma fibrinogen level and fibrin-based clot strength (FIBTEM) in major trauma: a retrospective study

Table 3 Hemostatic therapy administered during the study

	FC group (n = 85)	FC–PCC group (n = 63)	FC–PCC–FFP group (n = 9)	p-value
RBC (Units)
ER and intra-operative	2 (0–3)	5 (3–7)	11 (8–20)	<0.0001
ICU	2 (0–3)	3 (1–5)	6.5 (5–12)	<0.0001
24h	3 (2–6)	8 (5–11)	21 (18–26)	<0.0001
Fibrinogen concentrate (g)
ER and intra-operative	3 (2–3)	6 (3–7)	9 (5–16)	<0.0001
ICU	0 (0–2)	2 (0–4)	4 (0–6)	0.0006
24h	3 (2–5)	7 (5–10)	15 (9–17)	<0.0001
PCC (Units)
ER and intra-operative		1200 (0–1800)	2400 (600–5100)	0.036
ICU		900 (0–1800)	1500 (0–2850)	0.34
24h		1800 (1200–2400)	4200 (3000–6150)	0.0029
FFP (Units)
ER and intra-operative			0 (0–6)
ICU			6 (0–10)
24h			6 (6–10)
Platelet concentrate (Units)
ER and intra-operative	0 (0–0)	0 (0–0)	2 (0–2)	<0.0001
ICU	0 (0–0)	0 (0–0)	2 (1–2)	<0.0001
24h	0 (0–0)	0 (0–0)	4 (2–4)	<0.0001
Tranexamic acid (g)
ER and intra-operative	0 (0–2)	0 (0–2)	0 (0–2)	0.0006
ICU	0 (0–0)	0 (0–0)	0 (0–0)	ns
24h	0 (0–2)	0 (0–2)	0 (0–2)	<0.0001

Data are presented as median (interquartile range). p-values are derived from the ANOVA or, for units of PCC, the Mann–Whitney U test; significance level p < 0.05.
FFP, fresh frozen plasma; ns, not significant; PCC, prothrombin complex concentrate; RBC, red blood cells.
FC group, patients receiving fibrinogen concentrate only; FC–PCC group, patients receiving fibrinogen concentrate and prothrombin complex concentrate; FC–PCC–FFP group, patients receiving fibrinogen concentrate, prothrombin complex concentrate and fresh frozen plasma.
Results are presented for the following periods of time: while patients were in the emergency room (ER) and undergoing surgery, while patients were in the intensive care unit (ICU), and the whole 24-hour period (24h) following ER admission.

ISSN: 1757-7241