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Table 3 Hemostatic therapy administered during the study

From: Impact of fibrinogen concentrate alone or with prothrombin complex concentrate (+/− fresh frozen plasma) on plasma fibrinogen level and fibrin-based clot strength (FIBTEM) in major trauma: a retrospective study

  FC group (n = 85) FC–PCC group (n = 63) FC–PCC–FFP group (n = 9) p-value
RBC (Units)     
ER and intra-operative 2 (0–3) 5 (3–7) 11 (8–20) <0.0001
ICU 2 (0–3) 3 (1–5) 6.5 (5–12) <0.0001
24h 3 (2–6) 8 (5–11) 21 (18–26) <0.0001
Fibrinogen concentrate (g)     
ER and intra-operative 3 (2–3) 6 (3–7) 9 (5–16) <0.0001
ICU 0 (0–2) 2 (0–4) 4 (0–6) 0.0006
24h 3 (2–5) 7 (5–10) 15 (9–17) <0.0001
PCC (Units)     
ER and intra-operative   1200 (0–1800) 2400 (600–5100) 0.036
ICU   900 (0–1800) 1500 (0–2850) 0.34
24h   1800 (1200–2400) 4200 (3000–6150) 0.0029
FFP (Units)     
ER and intra-operative    0 (0–6)  
ICU    6 (0–10)  
24h    6 (6–10)  
Platelet concentrate (Units)     
ER and intra-operative 0 (0–0) 0 (0–0) 2 (0–2) <0.0001
ICU 0 (0–0) 0 (0–0) 2 (1–2) <0.0001
24h 0 (0–0) 0 (0–0) 4 (2–4) <0.0001
Tranexamic acid (g)     
ER and intra-operative 0 (0–2) 0 (0–2) 0 (0–2) 0.0006
ICU 0 (0–0) 0 (0–0) 0 (0–0) ns
24h 0 (0–2) 0 (0–2) 0 (0–2) <0.0001
  1. Data are presented as median (interquartile range). p-values are derived from the ANOVA or, for units of PCC, the Mann–Whitney U test; significance level p < 0.05.
  2. FFP, fresh frozen plasma; ns, not significant; PCC, prothrombin complex concentrate; RBC, red blood cells.
  3. FC group, patients receiving fibrinogen concentrate only; FC–PCC group, patients receiving fibrinogen concentrate and prothrombin complex concentrate; FC–PCC–FFP group, patients receiving fibrinogen concentrate, prothrombin complex concentrate and fresh frozen plasma.
  4. Results are presented for the following periods of time: while patients were in the emergency room (ER) and undergoing surgery, while patients were in the intensive care unit (ICU), and the whole 24-hour period (24h) following ER admission.