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Table 1 Clinical data upon emergency room (ER) admission of patients receiving fibrinogen concentrate (FC)

From: Impact of fibrinogen concentrate alone or with prothrombin complex concentrate (+/− fresh frozen plasma) on plasma fibrinogen level and fibrin-based clot strength (FIBTEM) in major trauma: a retrospective study

  FC group (n = 85) FC–PCC group (n = 63) FC–PCC–FFP group (n = 9) p-value
Age (years) 40 (27–58) 45 (26–57) 49 (29–58) 0.99
Age >55 years, n (%) 24 (28%) 17 (27%) 2 (22%) 0.93
Male, n (%) 73 (86%) 51 (81%) 6 (67%) 0.31
Systolic BP (mmHg) 110 (90–131) 88 (75–125) 83 (75–105) 0.0068
Systolic BP ≤90 mmHg , n (%) 23 (27%) 32 (31%) 5 (56%) 0.0073
Temperature (°C) 35.2 (34.1–36.0) 35.7 (34.0–36.35) 35.9 (35.2–36.4) 0.39
ISS 27 (20–34) 34 (26–43) 50 (42–58) <0.0001
NISS 30 (26–41) 38 (28–50) 50 (43–58) 0.0002
ISS ≥16, n (%) 76 (89%) 63 (100%) 9 (100%) 0.018
ISS ≥25, n (%) 53 (62%) 48 (76%) 9 (100%) 0.025
GCS 12 (5–15) 10 (5–15) 7 (4–15) 0.58
pH 7.33 (7.28–7.38) 7.28 (7.22–7.35) 7.26 (7.17–7.35) 0.0025
BD (mmol/L) 3.7 (1.9–5.8) 5.6 (3.4–8.5) 5.8 (4.1–10.7) 0.0005
Lactate (mmol/L) 2.12 (1.56–3.48) 3.10 (2.27–5.45) 7.51 (4.51–8.78) 0.0001
Acute operative intervention*, n (%) 74 (87%) 57 (91%) 9 (100%) 0.45
  1. Data are presented as median (interquartile range) or number (percentage of patients). p-values are derived from the ANOVA or chi-square test; significance level p < 0.05.
  2. *All types of intervention and damage control (e.g. orthopaedic surgery).
  3. BD, base deficit; BP, blood pressure; ISS, injury severity score; NISS, new injury severity score; GCS, Glasgow coma scale.
  4. FC group, patients receiving fibrinogen concentrate only; FC–PCC group, patients receiving fibrinogen concentrate and prothrombin complex concentrate; FC–PCC–FFP group, patients receiving fibrinogen concentrate, prothrombin complex concentrate and fresh frozen plasma.