Fibrinogen concentration and FIBTEM test results. For the fibrin-based FIBTEM assay, clot amplitude at 10 min running time (CA10) is shown. Results were obtained at the following timepoints: upon admission to the emergency room (ER), upon admission to the intensive care unit (ICU) and approximately 24 hours (24h) after ER admission. Data are presented as median values with interquartile ranges; error bars represent minimum and maximum values. FIBTEM, extrinsically activated test of fibrin-based clotting (cytochalasin D inhibits platelet contribution to clot strength); CA10, clot amplitude at 10 minutes. FC group, patients receiving fibrinogen concentrate only; FC–PCC group, patients receiving fibrinogen concentrate and prothrombin complex concentrate; FC–PCC–FFP group, patients receiving fibrinogen concentrate, prothrombin complex concentrate and fresh frozen plasma. *p < 0.05, **p < 0.01, ***p < 0.001, ns = not significant (unpaired t-test or Mann–Whitney U test).