|
RIFLE category and component
|
HES n/N (%)
|
Saline n/N (%)
|
Relative risk 95% confidence interval
|
p
|
Result
|
|---|
|
RIFLE-R (risk)
|
1788/3309 (54.0)
|
1912/3335 (57.3)
|
0.94 (0.90-0.98)
|
0.007
|
HES better
|
|
Creatinine increase (x1,5) from baseline
|
462/3149 (14.7)
|
415/3171 (13.1)
|
1.12 (0.99-1.27)
|
0.07
|
n.s.
|
|
Urine output <0.5 ml/kg/h x 6 h
|
1701/3230 (52.7)
|
1846/3266 (56.5)
|
0.93 (0.89-0.97)
|
0.002
|
HES better
|
|
RIFLE-I (injury)
|
1130/3265 (34.6)
|
1253/3300 (38.0)
|
0.91 (0.85-0.97)
|
0.005
|
HES better
|
|
Creatinine increase (x2) from baseline
|
245/3149 (7.8)
|
191/3171 (6.0)
|
1.29 (1.08-1.55)
|
0.006
|
Saline better
|
|
Urine output <0.5 ml/kg/h x 12 h
|
1077/2977 (36.2)
|
1200/3024 (39.7)
|
0.91 (0.85-0.97)
|
0.005
|
HES better
|
- The results clearly contradict the statement in the original manuscript that in subgroup analyses “post-hoc tests show a higher relative risk of meeting the criteria for the risk of kidney dysfunction (RIFLE-R) or kidney injury (RIFLE-I) in the HES group than in the saline group”.
