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Table 1 A modified excerpt of the original ‘Figure S3’ in the supplementary appendix of the CHEST trial[13]

From: Hydroxyethyl starch - the importance of being earnest

RIFLE category and component HES n/N (%) Saline n/N (%) Relative risk 95% confidence interval p Result
RIFLE-R (risk) 1788/3309 (54.0) 1912/3335 (57.3) 0.94 (0.90-0.98) 0.007 HES better
Creatinine increase (x1,5) from baseline 462/3149 (14.7) 415/3171 (13.1) 1.12 (0.99-1.27) 0.07 n.s.
Urine output <0.5 ml/kg/h x 6 h 1701/3230 (52.7) 1846/3266 (56.5) 0.93 (0.89-0.97) 0.002 HES better
RIFLE-I (injury) 1130/3265 (34.6) 1253/3300 (38.0) 0.91 (0.85-0.97) 0.005 HES better
Creatinine increase (x2) from baseline 245/3149 (7.8) 191/3171 (6.0) 1.29 (1.08-1.55) 0.006 Saline better
Urine output <0.5 ml/kg/h x 12 h 1077/2977 (36.2) 1200/3024 (39.7) 0.91 (0.85-0.97) 0.005 HES better
  1. The results clearly contradict the statement in the original manuscript that in subgroup analyses “post-hoc tests show a higher relative risk of meeting the criteria for the risk of kidney dysfunction (RIFLE-R) or kidney injury (RIFLE-I) in the HES group than in the saline group”.