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Table 3 Effects of added coagulation factors on coagulation measured with free oscillation rheometry (FOR)

From: Free oscillation rheometry monitoring of haemodilution and hypothermia and correction with fibrinogen and factor XIII concentrates

  Coagulation Factor
Variable Control Fibrinogen Fibrinogen + FXIII
COT1 (s) 20.7 19.4   19.0 **  
COT2 (s) 71.1 55.2   *** 53.1 ***  
G'max Fib1 (Pa) 506 585   ** 606 **  
G'max Fib2 (Pa) 20.5 31.0   *** 36.3 *** ††
G'max Fib1-2 (Pa) 485 554   ** 570 **  
  1. Effects on coagulation of the coagulation factors fibrinogen, fibrinogen with factor XIII (Fibrinogen + FXIII) or no addition of coagulation factor (Control). Data are estimated marginal means. COT1 and COT2 are coagulation time 1 and 2, respectively. The maximal clot strength is presented as G'max for Fib1 (without platelet inhibition) and G'max for Fib2 (with platelet inhibition). Platelet-dependent clot strength is presented by the difference between G'max for Fib1 and that of Fib2, denoted as G'max Fib1-2. ** and *** stands for p < 0.01 and p < 0.001, respectively, when the addition of coagulation factor was compared to the control group. †† and ††† stands for p < 0.01 and p < 0.001, respectively, when the addition of fibrinogen alone was compared to the addition of fibrinogen with FXIII. See text for details on interactions. N = 10.