| |
Coagulation Factor
|
|---|
|
Variable
|
Control
|
Fibrinogen
|
Fibrinogen + FXIII
|
|---|
|
COT1 (s)
|
20.7
|
19.4
| |
19.0
|
**
| |
|
COT2 (s)
|
71.1
|
55.2
|
***
|
53.1
|
***
| |
|
G'max Fib1 (Pa)
|
506
|
585
|
**
|
606
|
**
| |
|
G'max Fib2 (Pa)
|
20.5
|
31.0
|
***
|
36.3
|
***
|
††
|
|
G'max Fib1-2 (Pa)
|
485
|
554
|
**
|
570
|
**
| |
- Effects on coagulation of the coagulation factors fibrinogen, fibrinogen with factor XIII (Fibrinogen + FXIII) or no addition of coagulation factor (Control). Data are estimated marginal means. COT1 and COT2 are coagulation time 1 and 2, respectively. The maximal clot strength is presented as G'max for Fib1 (without platelet inhibition) and G'max for Fib2 (with platelet inhibition). Platelet-dependent clot strength is presented by the difference between G'max for Fib1 and that of Fib2, denoted as G'max Fib1-2. ** and *** stands for p < 0.01 and p < 0.001, respectively, when the addition of coagulation factor was compared to the control group. †† and ††† stands for p < 0.01 and p < 0.001, respectively, when the addition of fibrinogen alone was compared to the addition of fibrinogen with FXIII. See text for details on interactions. N = 10.
