| | Coagulation Factor |
|---|
Variable | Control | Fibrinogen | Fibrinogen + FXIII |
|---|
COT1 (s) | 20.7 | 19.4 | | 19.0 | ** | |
COT2 (s) | 71.1 | 55.2 | *** | 53.1 | *** | |
G'max Fib1 (Pa) | 506 | 585 | ** | 606 | ** | |
G'max Fib2 (Pa) | 20.5 | 31.0 | *** | 36.3 | *** | †† |
G'max Fib1-2 (Pa) | 485 | 554 | ** | 570 | ** | |
- Effects on coagulation of the coagulation factors fibrinogen, fibrinogen with factor XIII (Fibrinogen + FXIII) or no addition of coagulation factor (Control). Data are estimated marginal means. COT1 and COT2 are coagulation time 1 and 2, respectively. The maximal clot strength is presented as G'max for Fib1 (without platelet inhibition) and G'max for Fib2 (with platelet inhibition). Platelet-dependent clot strength is presented by the difference between G'max for Fib1 and that of Fib2, denoted as G'max Fib1-2. ** and *** stands for p < 0.01 and p < 0.001, respectively, when the addition of coagulation factor was compared to the control group. †† and ††† stands for p < 0.01 and p < 0.001, respectively, when the addition of fibrinogen alone was compared to the addition of fibrinogen with FXIII. See text for details on interactions. N = 10.
