Free oscillation rheometry monitoring of haemodilution and hypothermia and correction with fibrinogen and factor XIII concentrates

Table 2 Interaction effects of (a) temperature and the type of solution in haemodilution and (b) the type of solution in haemodilution and added coagulation factor

	(a) Temperature X solution			(b) Solution X coagulation factor
	Und	Und.	RA	Control vs.	Control vs.	Fibrinogen vs.
Variable	vs. RA	vs. HES	vs. HES	Fibr.	Fibr. + FXIII	Fibr. + FXIII
COT1 (s)	-	-	-	-	-	-
COT2 (s)	-	0.035	-	0.001	0.002	-
G'max Fib1 (Pa)	-	-	-	-	-	-
G'max Fib2 (Pa)	-	<0.001	0.003	<0.001	<0.001	<0.001
G'max Fib1-2 (Pa)	-	-	-	-	-	-

Significances (p-values) of the interaction effects. The left half of the table (a) shows the interaction between temperature (33°C versus 37°C) and solution (Und. = undiluted, RA, or HES), according to a two-way ANOVA (Temperature X Solution).
The right half of the table (b) shows the interaction between solution (RA or HES) and added coagulation factor (Control, i.e., no addition of coagulation factor, fibrinogen or fibrinogen with FXIII), according to a three-way ANOVA (Temperature X Solution X Coagulation Factor). Not shown from the latter ANOVA are the interactions of Temperature X Coagulation Factor. None of these interactions were significant. The maximal clot strength is presented as G'max for Fib1 (without platelet inhibition) and G'max for Fib2 (with platelet inhibition). Platelet-dependent clot strength is presented by the difference between G'max for Fib1 and that for Fib2, denoted as G'max Fib1-2. RA is Ringer’s acetate solution. HES is hydroxyethyl starch in saline. Interactions marked with - were not significant. N = 10.

ISSN: 1757-7241