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Table 1 Effects of hypothermia and haemodilution on coagulation measured with free oscillation rheometry (FOR)

From: Free oscillation rheometry monitoring of haemodilution and hypothermia and correction with fibrinogen and factor XIII concentrates

  Temperature Solution
Variable 37°C 33°C Undiluted RA HES
COT1 (s) 18.1 21.2 ** 17.6 20.1 ** 21.3 ***  
COT2 (s) 58.3 68.8 *** 48.5 55.5 ** 86.7 **
G'max Fib1 (Pa) 716 613 *** 983 617 *** 395 *** †††
G'max Fib2 (Pa) 31.7 24.5 *** 43.3 29.5 *** 11.5 *** †††
G'max Fib1-2 (Pa) 685 589 ** 940 587 *** 383 *** †††
  1. Effects on coagulation of hypothermia (33°C versus 37°C) and 33% haemodilution with RA or HES compared to undiluted blood, presented as estimated marginal means. COT1 and COT2 are coagulation time 1 and 2, respectively. The maximal clot strength is presented as G'max for Fib1 (without platelet inhibition) and G'max for Fib2 (with platelet inhibition). Platelet-dependent clot strength is presented by the difference between G'max for Fib1 and that for Fib2, denoted as G'max Fib1-2.
  2. ** and *** stands for p < 0.01 and p < 0.001, respectively, when the two temperatures were compared or when diluted blood (RA or HES) was compared to undiluted blood. †† and ††† stands for p < 0.01 and p < 0.001, respectively, when haemodilution with RA was compared to HES. See text for details on interactions. N = 10.