| |
Temperature
|
Solution
|
|---|
|
Variable
|
37°C
|
33°C
|
Undiluted
|
RA
|
HES
|
|---|
|
COT1 (s)
|
18.1
|
21.2
|
**
|
17.6
|
20.1
|
**
|
21.3
|
***
| |
|
COT2 (s)
|
58.3
|
68.8
|
***
|
48.5
|
55.5
|
**
|
86.7
|
**
|
†
|
|
G'max Fib1 (Pa)
|
716
|
613
|
***
|
983
|
617
|
***
|
395
|
***
|
†††
|
|
G'max Fib2 (Pa)
|
31.7
|
24.5
|
***
|
43.3
|
29.5
|
***
|
11.5
|
***
|
†††
|
|
G'max Fib1-2 (Pa)
|
685
|
589
|
**
|
940
|
587
|
***
|
383
|
***
|
†††
|
- Effects on coagulation of hypothermia (33°C versus 37°C) and 33% haemodilution with RA or HES compared to undiluted blood, presented as estimated marginal means. COT1 and COT2 are coagulation time 1 and 2, respectively. The maximal clot strength is presented as G'max for Fib1 (without platelet inhibition) and G'max for Fib2 (with platelet inhibition). Platelet-dependent clot strength is presented by the difference between G'max for Fib1 and that for Fib2, denoted as G'max Fib1-2.
- ** and *** stands for p < 0.01 and p < 0.001, respectively, when the two temperatures were compared or when diluted blood (RA or HES) was compared to undiluted blood. †† and ††† stands for p < 0.01 and p < 0.001, respectively, when haemodilution with RA was compared to HES. See text for details on interactions. N = 10.
