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Table 1 Effects of hypothermia and haemodilution on coagulation measured with free oscillation rheometry (FOR)

From: Free oscillation rheometry monitoring of haemodilution and hypothermia and correction with fibrinogen and factor XIII concentrates

 

Temperature

Solution

Variable

37°C

33°C

Undiluted

RA

HES

COT1 (s)

18.1

21.2

**

17.6

20.1

**

21.3

***

 

COT2 (s)

58.3

68.8

***

48.5

55.5

**

86.7

**

G'max Fib1 (Pa)

716

613

***

983

617

***

395

***

†††

G'max Fib2 (Pa)

31.7

24.5

***

43.3

29.5

***

11.5

***

†††

G'max Fib1-2 (Pa)

685

589

**

940

587

***

383

***

†††

  1. Effects on coagulation of hypothermia (33°C versus 37°C) and 33% haemodilution with RA or HES compared to undiluted blood, presented as estimated marginal means. COT1 and COT2 are coagulation time 1 and 2, respectively. The maximal clot strength is presented as G'max for Fib1 (without platelet inhibition) and G'max for Fib2 (with platelet inhibition). Platelet-dependent clot strength is presented by the difference between G'max for Fib1 and that for Fib2, denoted as G'max Fib1-2.
  2. ** and *** stands for p < 0.01 and p < 0.001, respectively, when the two temperatures were compared or when diluted blood (RA or HES) was compared to undiluted blood. †† and ††† stands for p < 0.01 and p < 0.001, respectively, when haemodilution with RA was compared to HES. See text for details on interactions. N = 10.