Effects of haemodilution and hypothermia on coagulation. Coagulation of undiluted, RA-diluted and HES-diluted blood at 33 and 37°C as assessed by FOR. The parameters COT1 (A), COT2 (B), maximum elasticity for FibScreen1 (C), maximum elasticity for FibScreen2 (D) and the difference in maximum elasticity for FibScreen1 and 2 (E) are shown. Coagulation time 1 (COT1) represents the beginning of clot formation and coagulation time 2 (COT2) a fully formed clot. G'max is the maximum elasticity of the fully formed clot. FibScreen1 (Fib1) denotes that thromboplastin was added to the sample and FibScreen2 (Fib2) indicates that thromboplastin and abciximab were added, the latter a potent platelet inhibitor. Thus, Fib1 G'max represents whole blood clot strength and Fib2 G'max fibrinogen-dependent clot strength. FS1 – FS2 G'max was calculated to represent platelet-dependent clot strength. N = 10. Bars are 95% CI.