Table 3 Observed DRPs
Involved organ system | Involved drugs† |
|---|---|
Electrolytes | |
Hyponatremia | Thiazide diuretics (14), Non-thiazide diuretics (2), Anticonvulsants (2), Antidepressants± (2), ACE/ARB blockers (1) |
Hypokalemia | Non-thiazide diuretics (3), Thiazide diuretics (1) |
Hyperkalemia | ACE/ARB blockers (1) |
Cardiovascular ‡ | |
Bradycardia | Beta blockers (1) |
Hypotension | Beta blockers (1) |
Acute heart failure | NSAID (1) |
Hypovolemia/orthostatic dysregulation | Thiazide diuretics (7), Non-thiazide diuretics (4), |
Kidney | |
Hypovolemia, prerenal azotemia | Non-thiazide diuretics (3), thiazide diuretics (1) |
Acute kidney injury | ACE/ARB blockers (1), NSAID (3) |
Coagulation system | |
Intracranial hemorrhage | Vitamin-K antagonists (1) |
Gastrointestinal | |
Nausea | Opioids (1), Antibiotics (1), Interferon γ (1) |
Gastric ulcer/Gastritis | NSAID (2) |
Central nervous system | |
Aggravation of Parkinson’s | Underdosing Anti-Parkinson drugs (1) |
Status epilepticus | Malcompliance anticonvulsants (2) |
Hematology | |
Neutropenic complication | Chemotherapy (1) |
Anemia | Underdosing of Darbepoetin alpha (1) |
Endocrine | |
Diabetes mellitus | Systemic steroids (1) |
Addison | systemic steroids (1) |
Other | |
Overdosing | Opioids (7), Benzodiazepines (5), Anticonvulsants (3), Neuroleptics (1) |
Falls | Neuroleptic (1) |
Tumor lysis syndrome | Chemotherapy (1) |
Abusus | Laxatives (1) |