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Table 3 Diagnostic performance of BNP0 and ΔBNP on clinical outcomes

From: Prognostic value of B-type natriuretic peptide (BNP) and its potential role in guiding fluid therapy in critically ill septic patients

Outcomes

AU-ROC

Cutoff (pg/ml)

Sensitivity

Specificity

LR+

LR−

BNP0

Mortality

0.71 (0.59-0.84)

>816

48.2

87.5

3.85

0.59

Duration of MV > 7 days

0.79 (0.62-0.85)

>929

57.1

88.2

4.86

0.49

LOS in ICU > 7 days

0.66 (0.53-0.79)

>828

40

89.2

3.70

0.67

LOS in hospital > 12 days

0.71 (0.58-0.83)

>709

60.6

70.6

2.06

0.56

ΔBNP

Mortality

0.58 (0.44-0.72)

>294

40.7

77.5

1.81

0.76

Duration of MV > 7 days

0.80 (0.60-0.99)

>108

52.9

85.7

3.71

0.55

LOS in ICU > 7 days

0.84 (0.74-0.93)

>101

73.0

80.0

3.65

0.34

LOS in hospital > 12 days

0.85 (0.75-0.94)

>114

73.5

87.9

6.07

0.30

  1. BNP0 represents the B-type natriuretic peptide measured on ICU entry; ΔBNP represents the difference between BNP measured on the third day and BNP0 (BNP1-BNP0);
  2. Abbreviation: LOS, length of stay; MV, mechanical ventilation.