Figure 2
From: Critical care considerations in the management of the trauma patient following initial resuscitation
Prolonged tissue hypoperfusion creates a cumulative “oxygen debt” directly related to the “dose” of shock, based on both the duration and depth of hypoperfusion. Eventually this results in irreversible disruption of homeostasis such that patients will not respond to resuscitative efforts even after the initial insults have been corrected [adopted from [9]].