| Acute respiratory failure with 1 of the following condition: |
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1. | SaO2 < 85% for at least 1 hour |
2. | Oxygenation Index >25 for at least 6 hours after ventilation's optimisation |
3. | PaO2/FiO2 < 100 with PEEP ≥ 10cmH2O for at least 6 hours after ventilation's optimization |
4. | Hypercapnia with pH < 7.25 |
5. | SvO2 < 65% with hematocrit > 30 and under vasoactive drugs infusion |