Figure 1

Results of whole blood coagulation and platelet function under dilution by HyperHaes and its contents. Panel A: Extrinsically activated measurements of maximum clot firmness (ExTEM-MCF in millimeter) and Panel B: coagulation time after extrinsically activation (CT in seconds). Panel C: Maximum clot firmness of fibrin polymerization (FibTEM-MCF in millimeter) and Panel D: AUC of platelet aggregation after thrombin activation (AUC in aggregation units (AU)*millimeter). Measurements were performed with respect to dilution of 5%, 10%, 20%, and 40%. Tested groups are HyperHaes (HH), hypertonic saline solution (HT), Haes 6% (HS) and isotonic saline solution (ISO). * are assigned with significantly different results as compared to baseline values. # are assigned with significantly different results as compared to HH results. Note that HH and HT treatment lead to comparable impairment of ExTEM-MCF and AUC indicating HT to be responsible for HH's impairment of platelet function and whole blood coagulation.