The molecular changes associated with induced therapeutic hypothermia. Minimal metabolic activity due to inactivation of Na+/K+ ATPase pump conserves ATP in the cell and abolishes the need for oxygen and substrates during the circulatory arrest. Induced hypothermia also affects several molecular pathways altering the expression of many intermediates and leads to decreased inflammation, decreased neutrophils migration and decrease apoptosis. Production of ROS is blunted as well. TNFR = Tumor Necrosis Factor Receptor. Cyt-C = Cytochrome C. ROS = Reactive Oxygen Species. STAT = Signal Transducers and Activators of Transcription. HSP 70 = Heat Shock Protein. JNK = stress-activated protein c-jun Kinase.