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Table 2 Clinical outcome studies reviewing the effects of red cell storage age, in order of publication

From: Blood transfusion in the critically ill: does storage age matter?

Author Study Population No. Patients Major Conclusion
Purdy et al.[18] Septic ICU patients 31 Patients who died received older RBC
Vamvakas et al.[31] CABG patients 416 Transfusion of RBC with longer storage time associated with pneumonia
Zallen et al.[19] Trauma patients who received 6-20 RBC in the first 12 hours post-injury 63 Patients who developed MOF received older blood (30 vs. 24 days)
Vamvakas et al.[32] CABG patients 268 Transfusion of old RBC was not associated with increased morbidity or mortality
Offner et al.[20] Trauma patients who received 6-20 RBC in the first 12 hours post-injury 62 Transfusion of old blood was associated with increase risk of infection
Keller et al.[21] Trauma patients who received ≥1 RBC within 48 hours of admission 86 Older RBC were associated with longer hospital length of stay
Murrell et al.[33] Trauma patients who received ≥1 RBC 275 Patients who received older RBC had longer length of ICU stay but no increased in-hospital mortality
Koch et al.[24] CABG patients who received exclusively young or old blood 6,002 Patients receiving old RBC had higher mortality (short and long term)
Weinberg et al.[22] Trauma patients who received ≥1 RBC within the first 24 hours post-injury 1,813 Blood storage age potentiated the increased odd of mortality seen with larger volumes of transfusion
Weinberg et al.[23] Less severely injured trauma patients who received no RBC in the first 48 hours post-injury 1,624 Transfusion of old blood was associated with increased mortality, renal failure, and pneumonia
  1. RBC = red blood cell unit