| Temperature | Solution |
---|
Variable | 37°C | 33°C | Undiluted | RA | HES |
---|
COT1 (s) | 18.1 | 21.2 | ** | 17.6 | 20.1 | ** | 21.3 | *** | |
COT2 (s) | 58.3 | 68.8 | *** | 48.5 | 55.5 | ** | 86.7 | ** | † |
G'max Fib1 (Pa) | 716 | 613 | *** | 983 | 617 | *** | 395 | *** | ††† |
G'max Fib2 (Pa) | 31.7 | 24.5 | *** | 43.3 | 29.5 | *** | 11.5 | *** | ††† |
G'max Fib1-2 (Pa) | 685 | 589 | ** | 940 | 587 | *** | 383 | *** | ††† |
- Effects on coagulation of hypothermia (33°C versus 37°C) and 33% haemodilution with RA or HES compared to undiluted blood, presented as estimated marginal means. COT1 and COT2 are coagulation time 1 and 2, respectively. The maximal clot strength is presented as G'max for Fib1 (without platelet inhibition) and G'max for Fib2 (with platelet inhibition). Platelet-dependent clot strength is presented by the difference between G'max for Fib1 and that for Fib2, denoted as G'max Fib1-2.
- ** and *** stands for p < 0.01 and p < 0.001, respectively, when the two temperatures were compared or when diluted blood (RA or HES) was compared to undiluted blood. †† and ††† stands for p < 0.01 and p < 0.001, respectively, when haemodilution with RA was compared to HES. See text for details on interactions. N = 10.